open access

Vol 10, No 6 (2014)
Review paper
Published online: 2015-01-07
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Prognostic factors in chronic lymphocytic leukemia

Piotr Stelmach, Jerzy Z. Błoński, Tadeusz Robak
Onkol. Prak. Klin 2014;10(6):322-329.

open access

Vol 10, No 6 (2014)
REVIEW ARTICLES
Published online: 2015-01-07

Abstract

Chronic lymphocytic leukemia (CLL) is a neoplasm with uniquely heterogeneous course, which still makes it difficult to decide about the onset time and the choice of therapy. For this reason recent research on this disease focus simultaneously on understanding its biology, discovering novel prognostic factors and on incorporating new therapeutic agents in the treatment of CLL. These efforts also aim at proposing new prognostic systems which combine clinical and biological aspects of the disease with special consideration of the results of cytogenetic and molecular tests. In this literature review we present the current knowledge about the value of novel and the applicability of traditional prognostic factors in CLL.

Abstract

Chronic lymphocytic leukemia (CLL) is a neoplasm with uniquely heterogeneous course, which still makes it difficult to decide about the onset time and the choice of therapy. For this reason recent research on this disease focus simultaneously on understanding its biology, discovering novel prognostic factors and on incorporating new therapeutic agents in the treatment of CLL. These efforts also aim at proposing new prognostic systems which combine clinical and biological aspects of the disease with special consideration of the results of cytogenetic and molecular tests. In this literature review we present the current knowledge about the value of novel and the applicability of traditional prognostic factors in CLL.

Get Citation

Keywords

CD38, chronic lymphocytic leukemia, prognostic factors, biologic factors, cytogenetic alterations, immunoglobulin abnormalities, Zap-70, IgVH, TP53, BIRC3, NOTCH1, SF3B

About this article
Title

Prognostic factors in chronic lymphocytic leukemia

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 6 (2014)

Article type

Review paper

Pages

322-329

Published online

2015-01-07

Bibliographic record

Onkol. Prak. Klin 2014;10(6):322-329.

Keywords

CD38
chronic lymphocytic leukemia
prognostic factors
biologic factors
cytogenetic alterations
immunoglobulin abnormalities
Zap-70
IgVH
TP53
BIRC3
NOTCH1
SF3B

Authors

Piotr Stelmach
Jerzy Z. Błoński
Tadeusz Robak

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