open access

Vol 10, No 5 (2014)
Other materials agreed with the Editors
Published online: 2014-11-18
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Colorectal cancer with potentially resectable hepatic metastases: optimizing treatment

Mathias Worni, Kevin N. Shah, Bryan M. Clary
Onkol. Prak. Klin 2014;10(5):270-282.

open access

Vol 10, No 5 (2014)
Onkologia na świecie
Published online: 2014-11-18

Abstract

Colorectal cancer is a common malignancy and often presents with synchronous or metachronous distant spread. For patients with hepatic metastases, resection is the principal curative option. Liberalization of the indications for hepatic resection has introduced a number of challenges related to the size, distribution, and number of metastases as well as the condition of the future liver remnant. Advances in systemic therapy have solidified its role as both an important adjunct to surgery and also for many patients as a mechanism to facilitate resection. In patients whose disease is marginally resectable as a consequence of the distribution of hepatic lesions that precludes complete resection or out of concern for the future liver remnant, a number of strategies have been advocated, including prehepatectomy systemic therapy, staged surgical approaches, ablative technologies, and preoperative portal vein embolization. It is the purpose of this review to discuss ways in which to optimize the treatment of patients with potentially resectable disease, specifically those who are judged to have “borderline” resectable situations.

Abstract

Colorectal cancer is a common malignancy and often presents with synchronous or metachronous distant spread. For patients with hepatic metastases, resection is the principal curative option. Liberalization of the indications for hepatic resection has introduced a number of challenges related to the size, distribution, and number of metastases as well as the condition of the future liver remnant. Advances in systemic therapy have solidified its role as both an important adjunct to surgery and also for many patients as a mechanism to facilitate resection. In patients whose disease is marginally resectable as a consequence of the distribution of hepatic lesions that precludes complete resection or out of concern for the future liver remnant, a number of strategies have been advocated, including prehepatectomy systemic therapy, staged surgical approaches, ablative technologies, and preoperative portal vein embolization. It is the purpose of this review to discuss ways in which to optimize the treatment of patients with potentially resectable disease, specifically those who are judged to have “borderline” resectable situations.
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Keywords

colorectal cancer, gastrointestinal cancers, hepatic metastases, future liver remnant, oncology

About this article
Title

Colorectal cancer with potentially resectable hepatic metastases: optimizing treatment

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 5 (2014)

Article type

Other materials agreed with the Editors

Pages

270-282

Published online

2014-11-18

Bibliographic record

Onkol. Prak. Klin 2014;10(5):270-282.

Keywords

colorectal cancer
gastrointestinal cancers
hepatic metastases
future liver remnant
oncology

Authors

Mathias Worni
Kevin N. Shah
Bryan M. Clary

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