Vol 10, No 3 (2014)
Guidelines / Expert consensus
Published online: 2014-07-30

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Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies

Paweł Krawczyk, Joanna Chorostowska-Wynimko, Rafał Dziadziuszko, Jacek Jassem, Maciej Krzakowski, Renata Langfort, Elżbieta Puacz, Bartosz Wasąg, Kamila Wojas-Krawczyk
Onkol. Prak. Klin 2014;10(3):131-137.


Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.

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