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Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies
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Abstract
Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.
Abstract
Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.
Keywords
non-small-cell lung cancer, EGFR gene mutations, ALK gene rearrangement, genetic diagnostic tests
About this articleTitle
Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies
Journal
Issue
Article type
Guidelines / Expert consensus
Pages
131-137
Published online
2014-07-30
Page views
607
Article views/downloads
3921
Bibliographic record
Onkol. Prak. Klin 2014;10(3):131-137.
Keywords
non-small-cell lung cancer
EGFR gene mutations
ALK gene rearrangement
genetic diagnostic tests
Authors
Paweł Krawczyk
Joanna Chorostowska-Wynimko
Rafał Dziadziuszko
Jacek Jassem
Maciej Krzakowski
Renata Langfort
Elżbieta Puacz
Bartosz Wasąg
Kamila Wojas-Krawczyk