open access

Vol 10, No 4 (2014)
Review paper
Published online: 2014-08-29
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Molecular determinants of lung cancer

Magdalena Potempa, Paweł Jonczyk, Marzena Zalewska-Ziob
Onkol. Prak. Klin 2014;10(4):199-211.

open access

Vol 10, No 4 (2014)
REVIEW ARTICLES
Published online: 2014-08-29

Abstract

Lung cancer is the most common malignant neoplasm and the main cause of human death. Despite persistant development in the dignostics and therapy process, 5-year survival is still unsatisfactory. It is caused mostly by detecting lung cancer in advanced stage and that is why there is no posibility for radical treatment resection. Diagnostic and therapeutical progress in molecular biology creates a chance to make overall survival longer. In this paper authors present molecular determinants of lung cancer including main functions of p53, Rb, p16. MYC, RAS proteins and consequences of mutations within the genes encoding them. There is also showed a role of growth factors, apoptosis, angiogenesis and telomerase in the oncogenic transformation. Beside this authors descibed genetics dycfunctions which may be a molecular predictive factos for lung cancer.

Abstract

Lung cancer is the most common malignant neoplasm and the main cause of human death. Despite persistant development in the dignostics and therapy process, 5-year survival is still unsatisfactory. It is caused mostly by detecting lung cancer in advanced stage and that is why there is no posibility for radical treatment resection. Diagnostic and therapeutical progress in molecular biology creates a chance to make overall survival longer. In this paper authors present molecular determinants of lung cancer including main functions of p53, Rb, p16. MYC, RAS proteins and consequences of mutations within the genes encoding them. There is also showed a role of growth factors, apoptosis, angiogenesis and telomerase in the oncogenic transformation. Beside this authors descibed genetics dycfunctions which may be a molecular predictive factos for lung cancer.

Get Citation

Keywords

lung cancer, molecular base of lung cancer, molecular predictive factors

About this article
Title

Molecular determinants of lung cancer

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 4 (2014)

Article type

Review paper

Pages

199-211

Published online

2014-08-29

Bibliographic record

Onkol. Prak. Klin 2014;10(4):199-211.

Keywords

lung cancer
molecular base of lung cancer
molecular predictive factors

Authors

Magdalena Potempa
Paweł Jonczyk
Marzena Zalewska-Ziob

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