Breast cancer recurrence after 15 years from primary treatment in patient cured of Hodgkin lymphoma and colorectal cancer — case report

Abstract

Multiple primary malignancies are rarely diagnosed in one patient. If they occur closely in time (according to some authors if they are diagnosed during one year) they are termed as synchronous tumors. If there is a longer time between their occurrence, they are metachronic and earlier oncological treatment (chemotherapy, radiotherapy) is considered as a probable carcinogen. There is a 6,6% to 9% risk of being diagnosed with second primary malignancy and less than 0,5% — with third or further. We present a case report of a 64-year old woman diagnosed with recurrence of breast cancer disseminated toher bones. At the age of 30 she was treated with radiotherapy of left supraclavicular and axillary lymph nodes due to Hodgkin lymphoma. When she was 49 she had mastectomy and axillary lymphadenectomy because of cancer of the left breast. Ten years later she had a resection of transverse colon because of cancer. Clinical data and data from literature indicate that most likely both breast cancer and colon cancer were sporadic, not related to the previous oncologic treatments.