Vol 9, No 5 (2013)
Review paper
Published online: 2013-12-03
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Systemic treatment for early breast cancer based on St. Gallen Guidelines 2013

Piotr J. Wysocki, Maciej Krzakowski
Onkol. Prak. Klin 2013;9(5):167-171.

Abstract

2013 St. Gallen International Expert Consensus has modified some issues on the treatment strategy of early breast cancer. The clinico-pathological differentiation of Luminal A and B tumors is now based not only on Ki67 expression (high proliferation threshold increased to ≥ 20%), but also on the level of PgR expression (≥ 20% requiredfor Luminal A). Based on recent results of ATLAS and aTTom trials, prolonged (up to 10 years) hormonal therapy with tamoxifen has been included in St. Gallen recommendations. For the first time the obesity has been commentedas a potential, negative predictive factor for aromatase inhibitors activity in premenopausal patients.

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