open access

Vol 9, No 5 (2013)
Review paper
Published online: 2013-12-03
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Systemic treatment for early breast cancer based on St. Gallen Guidelines 2013

Piotr J. Wysocki, Maciej Krzakowski
Onkol. Prak. Klin 2013;9(5):167-171.

open access

Vol 9, No 5 (2013)
REVIEW ARTICLES
Published online: 2013-12-03

Abstract

2013 St. Gallen International Expert Consensus has modified some issues on the treatment strategy of early breast cancer. The clinico-pathological differentiation of Luminal A and B tumors is now based not only on Ki67 expression (high proliferation threshold increased to ≥ 20%), but also on the level of PgR expression (≥ 20% requiredfor Luminal A). Based on recent results of ATLAS and aTTom trials, prolonged (up to 10 years) hormonal therapy with tamoxifen has been included in St. Gallen recommendations. For the first time the obesity has been commentedas a potential, negative predictive factor for aromatase inhibitors activity in premenopausal patients.

Abstract

2013 St. Gallen International Expert Consensus has modified some issues on the treatment strategy of early breast cancer. The clinico-pathological differentiation of Luminal A and B tumors is now based not only on Ki67 expression (high proliferation threshold increased to ≥ 20%), but also on the level of PgR expression (≥ 20% requiredfor Luminal A). Based on recent results of ATLAS and aTTom trials, prolonged (up to 10 years) hormonal therapy with tamoxifen has been included in St. Gallen recommendations. For the first time the obesity has been commentedas a potential, negative predictive factor for aromatase inhibitors activity in premenopausal patients.
Get Citation

Keywords

St. Gallen, early breast cancer, hormonal therapy, chemotherapy

About this article
Title

Systemic treatment for early breast cancer based on St. Gallen Guidelines 2013

Journal

Oncology in Clinical Practice

Issue

Vol 9, No 5 (2013)

Article type

Review paper

Pages

167-171

Published online

2013-12-03

Bibliographic record

Onkol. Prak. Klin 2013;9(5):167-171.

Keywords

St. Gallen
early breast cancer
hormonal therapy
chemotherapy

Authors

Piotr J. Wysocki
Maciej Krzakowski

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