open access

Vol 10, No 4 (2014)
Review paper
Published online: 2014-08-29
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Monoclonal antibodies in medical oncology — mechanism of action

Piotr J. Wysocki
Onkol. Prak. Klin 2014;10(4):175-183.

open access

Vol 10, No 4 (2014)
REVIEW ARTICLES
Published online: 2014-08-29

Abstract

Introduction of monoclonal antibodies into the armamentarium of systemic therapies has marked a breakthrough in oncology. In the case of several cancer types, monoclonal antibodies have significantly improved patients’ prognosis. Initially, antibodies were supposed to interact solely with surface molecules (receptors) acting as cytostatic drugs. However, it turned out that these immunologic agents attract and activate immune mechanisms involving antibody-dependent cellular cytotoxicity or complement activation.

Abstract

Introduction of monoclonal antibodies into the armamentarium of systemic therapies has marked a breakthrough in oncology. In the case of several cancer types, monoclonal antibodies have significantly improved patients’ prognosis. Initially, antibodies were supposed to interact solely with surface molecules (receptors) acting as cytostatic drugs. However, it turned out that these immunologic agents attract and activate immune mechanisms involving antibody-dependent cellular cytotoxicity or complement activation.

Get Citation

Keywords

monoclonal antibodies, oncolgy, cancer, ADCC, mechanism

About this article
Title

Monoclonal antibodies in medical oncology — mechanism of action

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 4 (2014)

Article type

Review paper

Pages

175-183

Published online

2014-08-29

Bibliographic record

Onkol. Prak. Klin 2014;10(4):175-183.

Keywords

monoclonal antibodies
oncolgy
cancer
ADCC
mechanism

Authors

Piotr J. Wysocki

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