open access

Vol 8, No 5 (2012)
Review paper
Published online: 2012-11-27
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Primary thymic tumors — state of the art

Kinga Winiarczyk, Magdalena Knetki-Wróblewska, Dariusz M. Kowalski, Maciej Krzakowski
Onkol. Prak. Klin 2012;8(5):209-217.

open access

Vol 8, No 5 (2012)
REVIEW ARTICLES
Published online: 2012-11-27

Abstract

Thymic malignancies are rare epithelial tumors — they constitute 0.2–1.5 of all neoplasms. Clinical stageand histological type are predictores of outcome. Surgery is the mainstay of the curative-intent treatmentof thymic tumors, in some cases adjuvant chemotherapy or radiotherapy are necessary. Multiagentchemotherapy — based on cisplatin, cycklophosphamid and doxorubicin — is indicated for patientwith recurrent or metastatic disease. Patients with positive somatostatin receptor scintigraphy positivetumors can be also treated with somatostatin analogues. Targeted therapies, such a belinostate, erlotinib,imatinib, are under investigation.

Abstract

Thymic malignancies are rare epithelial tumors — they constitute 0.2–1.5 of all neoplasms. Clinical stageand histological type are predictores of outcome. Surgery is the mainstay of the curative-intent treatmentof thymic tumors, in some cases adjuvant chemotherapy or radiotherapy are necessary. Multiagentchemotherapy — based on cisplatin, cycklophosphamid and doxorubicin — is indicated for patientwith recurrent or metastatic disease. Patients with positive somatostatin receptor scintigraphy positivetumors can be also treated with somatostatin analogues. Targeted therapies, such a belinostate, erlotinib,imatinib, are under investigation.
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Keywords

thymic neoplasms; chemotherapy; targeted therapy

About this article
Title

Primary thymic tumors — state of the art

Journal

Oncology in Clinical Practice

Issue

Vol 8, No 5 (2012)

Article type

Review paper

Pages

209-217

Published online

2012-11-27

Bibliographic record

Onkol. Prak. Klin 2012;8(5):209-217.

Keywords

thymic neoplasms
chemotherapy
targeted therapy

Authors

Kinga Winiarczyk
Magdalena Knetki-Wróblewska
Dariusz M. Kowalski
Maciej Krzakowski

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