open access

Vol 8, No 1 (2012)
Review paper
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Cardiac adverse events associated with antineoplastic treatment in elderly cancer patients

Katarzyna Soter, Aleksandra Łacko, Marcin Ekiert
Onkol. Prak. Klin 2012;8(1):20-28.

open access

Vol 8, No 1 (2012)
REVIEW ARTICLES

Abstract

Cardiac toxicities are potentially serious, even life-threatening side effects of antineoplastic treatment.Several commonly used cytotoxic and molecularly targeted agents are associated with risk of theseevents. Elderly cancer compared to younger are more susceptible to cardiac toxic effects. On the otherhand, not advanced age but pre-existing cardiac function and comorbidities are the most important riskfactors. Therefore it is essential to screen elderly patients for risk factors before initiating treatment, useagents with optimal therapeutic index, modify treatment schedule (weekly use or prolonging the infusiontime of anthracyclines) and perform rigorous monitoring of cardiac function.

Abstract

Cardiac toxicities are potentially serious, even life-threatening side effects of antineoplastic treatment.Several commonly used cytotoxic and molecularly targeted agents are associated with risk of theseevents. Elderly cancer compared to younger are more susceptible to cardiac toxic effects. On the otherhand, not advanced age but pre-existing cardiac function and comorbidities are the most important riskfactors. Therefore it is essential to screen elderly patients for risk factors before initiating treatment, useagents with optimal therapeutic index, modify treatment schedule (weekly use or prolonging the infusiontime of anthracyclines) and perform rigorous monitoring of cardiac function.
Get Citation

Keywords

cardiac toxicity, elderly, antineoplastic treatment

About this article
Title

Cardiac adverse events associated with antineoplastic treatment in elderly cancer patients

Journal

Oncology in Clinical Practice

Issue

Vol 8, No 1 (2012)

Article type

Review paper

Pages

20-28

Bibliographic record

Onkol. Prak. Klin 2012;8(1):20-28.

Keywords

cardiac toxicity
elderly
antineoplastic treatment

Authors

Katarzyna Soter
Aleksandra Łacko
Marcin Ekiert

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