A case of primary breast osteosarcoma
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Abstract
Primary breast osteosarcoma (PBOS) makes up less than 0.125% of all breast neoplasms and 12.5% of breast sarcomas.
Here, the case of a 53-year-old patient is presented who was treated at The Maria Skłodowska-Curie Institute of Oncology in Warsaw. Histopathological examination of core needle biopsy specimen revealed a neoplasm composed of atypic oval and spindle cells with chondroid differentiation as well as osteoid-like bands and myxoid stroma. The patient underwent a simple mastectomy with lymph node dissection. Histopathological evaluation of the surgical specimen confirmed the diagnosis of osteosarcoma G3, any features of metaplastic carcinoma as well as phyllodes tumor were excluded. Patient was given adjuvant radiotherapy after the operation. Seven months subsequent, multiple metastases in the lungs were found in a CT scan. The patient received chemotherapy, which, after three courses, resulted in a significant decrease of the metastases.
Addressed in discussion was the origin of this tumor, which is ambiguous, and a review the prognostic factors, of which, the most reliable is the size of the lesion and treatment methods, where wide excision definitely plays a major role.
Keywords: primary breast osteosarcomaosteosarcomabreast malignancy
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