Vol 20, Supp. A (2024)
Review paper
Published online: 2024-10-03
Efficacy of targeted therapies in the treatment of patients with melanoma harboring BRAF V600 mutation with central nervous system metastases
DOI: 10.5603/ocp.102692
Abstract
Brain metastases develop in almost half of patients with advanced melanoma, and in about 20% of patients, they are the first location of disseminated disease. In the past, the median survival of these patients was about four months, and one-year survival rate was only 10–20%. The implementation of new treatments, including stereotactic radiosurgery, immunotherapy and targeted therapy has significantly improved the prognosis. Approximately 50–60% of melanomas harbor mutations in the BRAF gene, so the use of BRAF/MEK inhibitors, which allow for a high rate of intracranial responses, is one of the management options. Many melanoma patients with brain metastases require various therapeutic methods, including local and systemic therapy and their selection and sequence depend on many clinical parameters. Diagnostic and therapeutic management in this group of patients is currently a great challenge. The aim of this publication is to summarize the effectiveness of targeted therapies in the treatment of melanoma patients with a mutation in the BRAF gene and central nervous system metastases.
Keywords: melanomaBRAF mutationtargeted therapybrain metastases
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