Comparison of clinical, pathological, and prognostic features of small bowel tumors
, 1, 1, 1, 1
Abstract
Introduction. Although approximately 75% of the digestive system’s length and almost 90% of its surface area consists of the small intestine, small bowel tumors are rare. In this study, we aimed to compare the clinical, pathological and prognostic features of small bowel tumors.
Material and methods. 107 patients diagnosed with small bowel tumor were evaluated retrospectively. Their clinical and pathological features were examined. The effects of the evaluated parameters on survival were analyzed, and overall survival rates were determined.
Results. Of the 107 patients diagnosed with small bowel malignancy included in the study, 44 (41%) were diagnosed with adenocarcinoma, 27 (25%) were diagnosed with GIST, 22 (20.6%) were diagnosed with NHL, and 14 (13.1%) were diagnosed with NET. Distant metastases were more common at diagnosis in adenocarcinoma patients [22 patients (50%)] than in GIST [5 patients (18.5%)] and NHL patients [3 patients (13.6%)] (p = 0.011, p = 0.006, respectively). The median OS in the adenocarcinoma group was 1.1 (min–max = 0.7–1.6) years, in the NET group it was 8.8 (min–max = 3.5–14.2) years, in the NHL group it was 10.7 (min–max = 1.9–19.6) years, but in the GIST group the median OS was could not be reached. OS differences between adenocarcinoma and other groups were statistically significant (p < 0.001).
Conclusions. The overall survival of adenocarcinoma was significantly lower than other small bowel tumor subgroups.
Keywords: small bowel tumorsGISTNHLNETadenocarcinoma
References
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016; 66(1): 7–30.
- Chow WH, Linet MS, McLaughlin JK, et al. Risk factors for small intestine cancer. Cancer Causes Control. 1993; 4(2): 163–169.
- Yamada A, Komaki Y, Komaki F, et al. Risk of gastrointestinal cancers in patients with cystic fibrosis: a systematic review and meta-analysis. Lancet Oncol. 2018; 19(6): 758–767.
- Puccini A, Battaglin F, Lenz HJ. Management of Advanced Small Bowel Cancer. Curr Treat Options Oncol. 2018; 19(12): 69.
- Bilimoria KY, Bentrem DJ, Wayne JD, et al. Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 2009; 249(1): 63–71.
- Oken MM, Creech RH, Dockerty DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982; 5(6): 649–655.
- MOERTEL CG, SAUER WG, DOCKERTY MB, et al. Life history of the carcinoid tumor of the small intestine. Cancer. 1961; 14: 901–912, doi: 10.1002/1097-0142(196109/10)14:5<901::aid-cncr2820140502>3.0.co;2-q.
- Minardi AJ, Zibari GB, Aultman DF, et al. Small-bowel tumors. J Am Coll Surg. 1998; 186(6): 664–668.
- Ciresi DL, Scholten DJ. The continuing clinical dilemma of primary tumors of the small intestine. Am Surg. 1995; 61(8): 698–702; discussion 702.
- Ojha A, Zacherl J, Scheuba C, et al. Primary small bowel malignancies: single-center results of three decades. J Clin Gastroenterol. 2000; 30(3): 289–293.
- Haselkorn T, Whittemore AS, Lilienfeld DE. Incidence of small bowel cancer in the United States and worldwide: geographic, temporal, and racial differences. Cancer Causes Control. 2005; 16(7): 781–787.
- Koc N, Uncu D, Karaahmetoglu S. Clinical features and prognostic factors in small bowel tumors: A retrospective evaluation of eighty cases. Annals of Medical Research. 2020; 27(1): 277.
- Weiss NS, Yang CP. Incidence of histologic types of cancer of the small intestine. J Natl Cancer Inst. 1987; 78(4): 653–656.
- Silva F, Bustamante M, Latorre G, et al. Clinical features and prognosis of malignant small bowel tumors: Experience from a university hospital in Chile. Gastroenterol Hepatol. 2024; 47(5): 491–499.
- Dabaja BS, Suki D, Pro B, et al. Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer. 2004; 101(3): 518–526.
- Shimizu N, Kuramoto S, Mimura T, et al. Leiomyosarcoma originating in Meckel's diverticulum: report of a case and a review of 59 cases in the English literature. Surg Today. 1997; 27(6): 546–549.
- Meijer LL, Alberga AJ, de Bakker JK, et al. Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis. Ann Surg Oncol. 2018; 25(9): 2681–2692.
- Ocasio Quinones GA, Khan Suheb MZ, Woolf A. Small Bowel Cancer. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC. ; 2024.