Locally advanced thoracic NUT carcinoma — a case report and literature review
Abstract
NUT carcinoma is an extremely rare and aggressive cancer. It is characterised by the presence of a nuclear protein gene rearrangement (NUTM1) on chromosome 15q14. Nut carcinoma can occur at any age but mainly in third decade. Patients with NUT carcinoma have affects diffrent organs, mainly in the midline of the body. Average overall survival patients with nut carcinoma does not exceed one year. The very rapid course of the disease, non-specific symptoms and the lack of specific treatment guidelines constitute a therapeutic challenge for oncologists. New treatment standards are needed. In our case report, we proposed a treatment method that showed clinical benefit.
Keywords: NUTNUT carcinomagene rearrangement
References
- Lauer UM, Hinterleitner M, Horger M, et al. NUT Carcinoma-An Underdiagnosed Malignancy. Front Oncol. 2022; 12: 914031.
- French CA. NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. Pathol Int. 2018; 68(11): 583–595.
- Alekseyenko AA, Walsh EM, Wang X, et al. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev. 2015; 29(14): 1507–1523.
- Chen J, Li M, Lu H. Nuclear protein in testis carcinoma of the lung. Transl Oncol. 2023; 30: 101640.
- Yuan J, Xu Z, Guo Y. Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review. Curr Oncol. 2022; 29(10): 6807–6815.
- Hellquist H, French CA, Bishop JA, et al. NUT midline carcinoma of the larynx: an international series and review of the literature. Histopathology. 2017; 70(6): 861–868.
- Giridhar P, Mallick S, Kashyap L, et al. Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. Eur Arch Otorhinolaryngol. 2018; 275(3): 815–821.
- Luo J, Sanchez M, Lee E, et al. Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma. J Thorac Oncol. 2024; 19(5): 829–838.
- Kloker LD, Sidiras M, Flaadt T, et al. Clinical management of NUT carcinoma (NC) in Germany: Analysis of survival, therapy response, tumor markers and tumor genome sequencing in 35 adult patients. Lung Cancer. 2024; 189: 107496.