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Published online: 2024-08-12

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Mobile applications in treatment of cancer pain — a systematic review

Barbara Kopczyńska1, Rafał Dyrda2, Oliwia Czyżniewska3, Natalia Wierzejska1, Mikołaj Domański1, Karina Otręba1, Karolina Czupryńska1, Julia Szałajska1, Maria Wojcieszek1

Abstract

Introduction. Chronic pain is often the greatest burden cancer patients experience, impacting their quality of life and daily functioning. Mobile applications are increasingly being utilized in the treatment of chronic diseases. Our review aimed to research whether mobile applications are effective in the treatment of cancer pain. 

Methods. Searches were conducted at the beginning of April 2024. Relevant studies were identified through databases including PubMed, Embase, the Cochrane Library, and Web of Science. The effects of apps were assessed by meta-analysis and descriptive analysis. 

Results. In randomized control trials (RCT), the estimated standardized mean difference in pain reduction between combined trial and control groups based on the random effects model was –0.3879 (95% CI from –1.06 to 0.29) and was not statistically significant (z = –1.13; p = 0.26). The data was heterogenous (Q = 25.99; p < 0.0001; I2 = 92.49%). In single-arm studies, the estimated average standardized mean difference based on the RE model was –0.4015 (95% CI from –0.59 to –0.22). The outcome was significant (z = –4.28; p < 0.0001) and the data were homogenous (Q = 2.16; p = 0.54; I2 = 0.00%). The results of other studies where we conducted descriptive analysis were statistically significant and showed cancer pain reduction using different scales. 

Conclusions. Our analysis indicates that applications can be effective in managing cancer pain. Modern apps, with their advanced algorithms, show promise for future cancer pain treatment. However, our analysis was limited by lack of data on pain control prevalence in oncological populations, highlighting the need for more high-quality RCTs on larger patient groups.

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References

  1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3): 229–263.
  2. Snijders RAH, Brom L, Theunissen M, et al. Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis. Cancers (Basel). 2023; 15(3).
  3. Mestdagh F, Steyaert A, Lavand'homme P. Cancer Pain Management: A Narrative Review of Current Concepts, Strategies, and Techniques. Curr Oncol. 2023; 30(7): 6838–6858.
  4. van den Beuken-van Everdingen MHJ, Hochstenbach LMJ, Joosten EAJ, et al. Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis. J Pain Symptom Manage. 2016; 51(6): 1070–1090.e9.
  5. Roberto A, Greco MT, Uggeri S, et al. Living systematic review to assess the analgesic undertreatment in cancer patients. Pain Pract. 2022; 22(4): 487–496.
  6. Mercadante S, Portenoy RK. Understanding the Chameleonic Breakthrough Cancer Pain. Drugs. 2021; 81(4): 411–418.
  7. Lalloo C, Jibb L, Rivera J, et al. “There’s a Pain App for That”. Clin J Pain. 2015; 31(6): 557–563.
  8. Lara-Solares A, Ahumada Olea M, Basantes Pinos Ad, et al. Latin-American guidelines for cancer pain management. Pain Manag. 2017; 7(4): 287–298.
  9. Maaß L, Freye M, Pan CC, et al. The Definitions of Health Apps and Medical Apps From the Perspective of Public Health and Law: Qualitative Analysis of an Interdisciplinary Literature Overview. JMIR Mhealth Uhealth. 2022; 10(10): e37980.
  10. Biswas M, Tania MH, Kaiser MS, et al. ACCU3RATE: A mobile health application rating scale based on user reviews. PLoS One. 2021; 16(12): e0258050.
  11. Klasnja P, Pratt W. Healthcare in the pocket: mapping the space of mobile-phone health interventions. J Biomed Inform. 2012; 45(1): 184–198.
  12. Ryan EA, Holland J, Stroulia E, et al. Improved A1C Levels in Type 1 Diabetes with Smartphone App Use. Can J Diabetes. 2017; 41(1): 33–40.
  13. Cui M, Wu X, Mao J, et al. T2DM Self-Management via Smartphone Applications: A Systematic Review and Meta-Analysis. PLoS One. 2016; 11(11): e0166718.
  14. Farzandipour M, Nabovati E, Sharif R, et al. Patient Self-Management of Asthma Using Mobile Health Applications: A Systematic Review of the Functionalities and Effects. Appl Clin Inform. 2017; 8(4): 1068–1081.
  15. Debon R, Coleone JD, Bellei EA, et al. Mobile health applications for chronic diseases: A systematic review of features for lifestyle improvement. Diabetes Metab Syndr. 2019; 13(4): 2507–2512.
  16. Becker S, Miron-Shatz T, Schumacher N, et al. mHealth 2.0: Experiences, Possibilities, and Perspectives. JMIR Mhealth Uhealth. 2014; 2(2): e24.
  17. Thurnheer SE, Gravestock I, Pichierri G, et al. Benefits of Mobile Apps in Pain Management: Systematic Review. JMIR Mhealth Uhealth. 2018; 6(10): e11231.
  18. Zheng C, Chen Xu, Weng L, et al. Benefits of Mobile Apps for Cancer Pain Management: Systematic Review. JMIR Mhealth Uhealth. 2020; 8(1): e17055.
  19. Strasser F, Blum D, von Moos R, et al. Swiss Group for Clinical Cancer Research (SAKK). The effect of real-time electronic monitoring of patient-reported symptoms and clinical syndromes in outpatient workflow of medical oncologists: E-MOSAIC, a multicenter cluster-randomized phase III study (SAKK 95/06). Ann Oncol. 2016; 27(2): 324–332.
  20. de la Vega R, Miró J. mHealth: a strategic field without a solid scientific soul. a systematic review of pain-related apps. PLoS One. 2014; 9(7): e101312.
  21. Weng L, Lin W, Lin X, et al. Randomized controlled trial of an app for cancer pain management. Support Care Cancer. 2024; 32(4): 244.
  22. Simon J, Schepers S, Gorp Mv, et al. Pain monitoring app leads to less pain in children with cancer at home: Results of a randomized controlled trial. Cancer. 2023; 130(13): 2339–2350.
  23. Hunter JF, Acevedo AM, Gago-Masague S, et al. A pilot study of the preliminary efficacy of Pain Buddy: A novel intervention for the management of children's cancer-related pain. Pediatr Blood Cancer. 2020; 67(10): e28278.
  24. Yang J, Weng L, Chen Z, et al. Development and Testing of a Mobile App for Pain Management Among Cancer Patients Discharged From Hospital Treatment: Randomized Controlled Trial. JMIR Mhealth Uhealth. 2019; 7(5): e12542.
  25. Kamdar M, Centi A, Agboola S, et al. A randomized controlled trial of a novel artificial intelligence-based smartphone application to optimize the management of cancer-related pain. J Clin Oncol. 2019; 37(15_suppl): 11514–11514.
  26. Smith SK, MacDermott K, Amarasekara S, et al. Reimagine: a randomized controlled trial of an online, symptom self-management curriculum among breast cancer survivors. Support Care Cancer. 2019; 27(5): 1775–1781.
  27. Sun Y, Jiang F, Gu JJ, et al. Development and Testing of an Intelligent Pain Management System (IPMS) on Mobile Phones Through a Randomized Trial Among Chinese Cancer Patients: A New Approach in Cancer Pain Management. JMIR Mhealth Uhealth. 2017; 5(7): e108.
  28. Somers TJ, Kelleher SA, Westbrook KW, et al. A Small Randomized Controlled Pilot Trial Comparing Mobile and Traditional Pain Coping Skills Training Protocols for Cancer Patients with Pain. Pain Res Treat. 2016; 2016: 2473629.
  29. Yun YHo, Lee KS, Kim YW, et al. Web-based tailored education program for disease-free cancer survivors with cancer-related fatigue: a randomized controlled trial. J Clin Oncol. 2012; 30(12): 1296–1303.
  30. Masiero M, Filipponi C, Fragale E, et al. Support for Chronic Pain Management for Breast Cancer Survivors Through Novel Digital Health Ecosystems: Pilot Usability Study of the PainRELife Mobile App. JMIR Form Res. 2024; 8: e51021.
  31. Bentsen L, Hanghøj S, Hjerming M, et al. Development of Quality of Life in Adolescents and Young Adults With Cancer Using a Patient Support Smartphone App: Prepost Interventional Study. JMIR Cancer. 2023; 9: e49735.
  32. Mohammadzadeh Z, Eghtedar S, Ayatollahi H, et al. Effectiveness of a self-management mobile app on the quality of life of women with breast cancer: a study in a developing country. BMC Womens Health. 2022; 22(1): 446.
  33. Park S, Kim JiY, Lee JC, et al. Mobile Phone App-Based Pulmonary Rehabilitation for Chemotherapy-Treated Patients With Advanced Lung Cancer: Pilot Study. JMIR Mhealth Uhealth. 2019; 7(2): e11094.
  34. Dorfman CS, Kelleher SA, Winger JG, et al. Development and pilot testing of an mHealth behavioral cancer pain protocol for medically underserved communities. J Psychosoc Oncol. 2019; 37(3): 335–349.
  35. Oldenmenger WH, Baan MAG, van der Rijt CCD. Development and feasibility of a web application to monitor patients' cancer-related pain. Support Care Cancer. 2018; 26(2): 635–642.
  36. Jibb LA, Stevens BJ, Nathan PC, et al. Implementation and preliminary effectiveness of a real-time pain management smartphone app for adolescents with cancer: A multicenter pilot clinical study. Pediatr Blood Cancer. 2017; 64(10).
  37. Jacob E, Mack AK, Savedra M, et al. Adolescent pediatric pain tool for multidimensional measurement of pain in children and adolescents. Pain Manag Nurs. 2014; 15(3): 694–706.
  38. Byambasuren O, Sanders S, Beller E, et al. Prescribable mHealth apps identified from an overview of systematic reviews. NPJ Digit Med. 2018; 1: 12.
  39. Bae WK, Kwon J, Lee HW, et al. Feasibility and accessibility of electronic patient-reported outcome measures using a smartphone during routine chemotherapy: a pilot study. Support Care Cancer. 2018; 26(11): 3721–3728.