open access

Vol 26 (2023): Continuous Publishing
Clinical vignette
Submitted: 2022-06-06
Accepted: 2022-09-04
Published online: 2022-10-28
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Role of [18F]FDG PET/CT in the differential diagnosis of a supraclavicular lump: neurofibromatosis disease

Ana Moreno-Ballesteros1, María De Bonilla-Candau2, Javier Mohigefer3, Marta Moreno-Ballesteros4, Francisco Javier Garcia-Gomez1
·
Nucl. Med. Rev 2023;26:40-41.
Affiliations
  1. Servicio de Medicina Nuclear, Hospital Universitario Virgen Macarena, Sevilla, Spain
  2. Servicio de Medicina Nuclear, Hospital Universitario Puerta del Mar, Cadiz, Spain
  3. Servicio de Anatomia Patologica, Hospital Universitario Virgen Macarena, Sevilla, Spain
  4. Servicio de Cirugía General, Hospital de Merida, Badajoz, Spain

open access

Vol 26 (2023): Continuous Publishing
Clinical vignette
Submitted: 2022-06-06
Accepted: 2022-09-04
Published online: 2022-10-28

Abstract

We report a 31-year-old male with a history of left forearm neuroma surgically removed, consulting for a supraclavicular bultoma congruent with the supradiaphragmatic lymphoproliferative syndrome in computed tomography (CT) scan. [18F]FDG PET/CT images helped to establish the most diagnostic yield lesion for the biopsy, and allowed an accurate staging of the neurofibromatosis (NF) disease, leading to the most appropriate therapeutic option for the patient.

Abstract

We report a 31-year-old male with a history of left forearm neuroma surgically removed, consulting for a supraclavicular bultoma congruent with the supradiaphragmatic lymphoproliferative syndrome in computed tomography (CT) scan. [18F]FDG PET/CT images helped to establish the most diagnostic yield lesion for the biopsy, and allowed an accurate staging of the neurofibromatosis (NF) disease, leading to the most appropriate therapeutic option for the patient.

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Keywords

[18F]FDG; NF; PET/CT; neurofibroma; differential diagnosis; bultoma

About this article
Title

Role of [18F]FDG PET/CT in the differential diagnosis of a supraclavicular lump: neurofibromatosis disease

Journal

Nuclear Medicine Review

Issue

Vol 26 (2023): Continuous Publishing

Article type

Clinical vignette

Pages

40-41

Published online

2022-10-28

Page views

2812

Article views/downloads

273

DOI

10.5603/NMR.a2022.0043

Bibliographic record

Nucl. Med. Rev 2023;26:40-41.

Keywords

[18F]FDG
NF
PET/CT
neurofibroma
differential diagnosis
bultoma

Authors

Ana Moreno-Ballesteros
María De Bonilla-Candau
Javier Mohigefer
Marta Moreno-Ballesteros
Francisco Javier Garcia-Gomez

References (9)
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  2. Strike SA, Puhaindran ME. Nerve tumors of the upper extremity. Clin Plast Surg. 2019; 46(3): 347–350.
  3. Obuchowski NA. Receiver operating characteristic curves and their use in radiology. Radiology. 2003; 229(1): 3–8.
  4. Mantaka P, Strauss AD, Moehler M, et al. Detection of treated liver metastases using fluorine-18-fluordeoxyglucose (FDG) and positron emission tomography (PET). Anticancer Res. 1999; 19: 4443–4450.
  5. Chirindel A, Chaudhry M, Blakeley JO, et al. 18F-FDG PET/CT qualitative and quantitative evaluation in neurofibromatosis type 1 patients for detection of malignant transformation: comparison of early to delayed imaging with and without liver activity normalization. J Nucl Med. 2015; 56(3): 379–385.
  6. Van Der Gucht A, Zehou O, Djelbani-Ahmed S, et al. Metabolic tumour burden measured by 18F-FDG PET/CT predicts malignant transformation in patients with neurofibromatosis type-1. PLoS One. 2016; 11(3): e0151809.
  7. Ahlawat S, Blakeley J, Montgomery E, et al. Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging. Skeletal Radiol. 2013; 42(9): 1317–1322.
  8. Brinkman M, Jentjens S, Boone K, et al. Evaluation of the most commonly used (semi-)quantitative parameters of 18F-FDG PET/CT to detect malignant transformation of neurofibromas in neurofibromatosis type 1. Nucl Med Commun. 2018; 39(11): 961–968.
  9. Gross AM, Wolters PL, Dombi E, et al. Selumetinib in children with inoperable plexiform neurofibromas. N Engl J Med. 2020; 382(15): 1430–1442.

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