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The scintigraphic diagnosis of cardiac amyloidosis. An expert opinion endorsed by the Section of Nuclear Medicine of the Polish Cardiac Society and the Polish Nuclear Medicine Society
, 3, 4, 5, 6, 7, 8, 9, 1, 12
Affiliations- Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
- Department of Nuclear Medicine, John Paul II Hospital, Krakow, Poland
- Department of Nuclear Medicine, Military Institute of Medicine, Warsaw, Poland
- Department of Cardiomyopathy, National Institute of Cardiology, Warsaw, Poland
- Department of Nuclear Medicine, National Institute of Cardiology, Warsaw, Poland
- Department of Nuclear Medicine,Nicolaus Copernicus University in Torun, Oncology Center, Bydgoszcz, Poland
- Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland
- Department of Nuclear Medicine, Medical University of Gdansk, Gdansk, Poland
- Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland
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Abstract
Amyloid transthyretin cardiomyopathy is a progressive disease that confers significant mortality. While it is relatively rare, the frequency of diagnoses has risen with the increased contribution of novel diagnostic approach over the last decade. Traditionally tissue biopsy was considered to be a gold standard for amyloidosis diagnosis. However, there are significant limitations in the wide application of this approach. A noninvasive imaging-based diagnostic algorithm has been substantially developed in recent years. Establishing radionuclide imaging standards may translate into a further enhancement of disease detection and improving prognosis in the group of patients. Therefore we present in the following document current evidence on the scintigraphic diagnosis of cardiac transthyretin amyloidosis. Moreover, we present standardized protocol for the acquisition and interpretation criteria in the scintigraphic evaluation of cardiac amyloidosis.
Abstract
Amyloid transthyretin cardiomyopathy is a progressive disease that confers significant mortality. While it is relatively rare, the frequency of diagnoses has risen with the increased contribution of novel diagnostic approach over the last decade. Traditionally tissue biopsy was considered to be a gold standard for amyloidosis diagnosis. However, there are significant limitations in the wide application of this approach. A noninvasive imaging-based diagnostic algorithm has been substantially developed in recent years. Establishing radionuclide imaging standards may translate into a further enhancement of disease detection and improving prognosis in the group of patients. Therefore we present in the following document current evidence on the scintigraphic diagnosis of cardiac transthyretin amyloidosis. Moreover, we present standardized protocol for the acquisition and interpretation criteria in the scintigraphic evaluation of cardiac amyloidosis.
Keywords
transthyretin amyloidosis; cardiomyopathy; scintigraphy
About this articleTitle
The scintigraphic diagnosis of cardiac amyloidosis. An expert opinion endorsed by the Section of Nuclear Medicine of the Polish Cardiac Society and the Polish Nuclear Medicine Society
Journal
Issue
Article type
Guidelines / Expert consensus
Pages
142-147
Published online
2022-07-26
Page views
4240
Article views/downloads
520
DOI
Pubmed
Bibliographic record
Nucl. Med. Rev 2022;25(2):142-147.
Keywords
transthyretin amyloidosis
cardiomyopathy
scintigraphy
Authors
Katarzyna Holcman
Miroslaw Dziuk
Jacek Grzybowski
Anna Teresinska
Bogdan Malkowski
Diana Jedrzejuk
Bogna Brockhuis
Rafał Czepczynski
Lidia Tomkiewicz-Pajak
Magdalena Kostkiewicz
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