open access
Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE
- Nuclear Medicine Center, Jam Hospital, Tehran, Iran
- Department of Surgery, Khatam-al-Anbia Hospital, Tehran, Iran
- Khatam PET/CT center, Khatam-al-Anbia Hospital, Tehran, Iran
- Department of Nuclear Medicine, Hazrat-e-Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
- Nuclear Medicine Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
open access
Abstract
A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.
Abstract
A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.
Keywords
NET; PRRT; cutaneous; extravasation; [177Lu]Lu-DOTATATE
Title
Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE
Journal
Issue
Article type
Clinical vignette
Pages
136-137
Published online
2022-06-21
Page views
4233
Article views/downloads
591
DOI
Pubmed
Bibliographic record
Nucl. Med. Rev 2022;25(2):136-137.
Keywords
NET
PRRT
cutaneous
extravasation
[177Lu]Lu-DOTATATE
Authors
Ghasemali Divband
Seyed Hootan Alavi
Zohre Adinehpour
Forough Kalantari
Soroush Zarehparvar Moghadam