open access

Vol 25, No 2 (2022)
Clinical vignette
Submitted: 2022-01-11
Accepted: 2022-04-27
Published online: 2022-06-21
Get Citation

Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE

Ghasemali Divband1, Seyed Hootan Alavi2, Zohre Adinehpour3, Forough Kalantari4, Soroush Zarehparvar Moghadam5
·
Pubmed: 35848524
·
Nucl. Med. Rev 2022;25(2):136-137.
Affiliations
  1. Nuclear Medicine Center, Jam Hospital, Tehran, Iran
  2. Department of Surgery, Khatam-al-Anbia Hospital, Tehran, Iran
  3. Khatam PET/CT center, Khatam-al-Anbia Hospital, Tehran, Iran
  4. Department of Nuclear Medicine, Hazrat-e-Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
  5. Nuclear Medicine Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

open access

Vol 25, No 2 (2022)
Clinical vignette
Submitted: 2022-01-11
Accepted: 2022-04-27
Published online: 2022-06-21

Abstract

A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.

Abstract

A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.

Get Citation

Keywords

NET; PRRT; cutaneous; extravasation; [177Lu]Lu-DOTATATE

About this article
Title

Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE

Journal

Nuclear Medicine Review

Issue

Vol 25, No 2 (2022)

Article type

Clinical vignette

Pages

136-137

Published online

2022-06-21

Page views

4233

Article views/downloads

591

DOI

10.5603/NMR.a2022.0030

Pubmed

35848524

Bibliographic record

Nucl. Med. Rev 2022;25(2):136-137.

Keywords

NET
PRRT
cutaneous
extravasation
[177Lu]Lu-DOTATATE

Authors

Ghasemali Divband
Seyed Hootan Alavi
Zohre Adinehpour
Forough Kalantari
Soroush Zarehparvar Moghadam

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

phone: +48 58 320 94 94, fax: +48 58 320 94 60, e-mail: viamedica@viamedica.pl