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open access

Vol 25, No 1 (2022)
Research paper
Submitted: 2021-06-27
Accepted: 2021-12-31
Published online: 2022-01-31
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Relationship between cerebral blood flow reduction patterns on scintigraphy and nonmotor symptoms in new-onset Lewy body disease

Yukinori Okada1, Makoto Shiraishi2, Koji Hori3, Keiichro Yamaguchi4, Yasuhiro Hasegawa2
DOI: 10.5603/NMR.a2022.0005
·
Pubmed: 35137933
·
Nucl. Med. Rev 2022;25(1):18-24.
Affiliations
  1. Department of Medical Radiology, St. Marianna University School of Medicine, Kawasaki, Japan
  2. Department of Internal Medicine and Brain Neurology, St. Marianna University School of Medicine, Kawasaki, Japan
  3. Department of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan
  4. Division of Advanced Tumor Imaging Research, St. Marianna University School of Medicine, Kawasaki, Japan

open access

Vol 25, No 1 (2022)
Original articles
Submitted: 2021-06-27
Accepted: 2021-12-31
Published online: 2022-01-31

Abstract

Background: This study aimed to investigate the relationship between patterns of reduced cerebral blood flow (CBF) evaluated by means of 123I-N-isopropyl-p-iodoamphetamine ([123I]IMP) scintigraphy and nonmotor symptoms in new-onset Lewy body disease (Parkinson’s disease and dementia with Lewy bodies [DLB]). Material and methods: Twenty-four patients diagnosed with new-onset Parkinson’s disease or DLB underwent [123I]IMP CBF scintigraphy at St. Marianna Medical University Hospital between January 1, 2010, and March 30, 2018. The reductions in CBF in various brain regions were analyzed using the three-dimensional stereotactic surface projection method and were compared to standard database values, yielding extent values (%). The extent values were evaluated in relation to the presence/absence of motor or nonmotor symptoms such as visual hallucinations, auditory hallucinations, delirium, depression, delusions, and dementia. Results: The extent value was 100% in the angular, supramarginal, and lingual gyri; 95% in the orbital gyri; and 92.6% in the fusiform gyri. The extent value in patients without hallucinations and those with visual hallucinations was 41.2% and 54.3%, respectively, in the frontal lobe (p = 0.02) and 33.3% and 51.0%, respectively, in the medial prefrontal gyri (p = 0.02). Age-adjusted multivariate analysis showed that extent values in the frontal lobe were associated with visual hallucinations (odds ratio: 1.09, 95% confidence interval 1.00–1.18, p = 0.04). Conclusions: The above results show that the CBF is reduced in several areas of the cerebral cortex and suggest an association between reduced blood flow in the frontal lobe and the appearance of visual hallucinations in patients with new-onset DLB.

Abstract

Background: This study aimed to investigate the relationship between patterns of reduced cerebral blood flow (CBF) evaluated by means of 123I-N-isopropyl-p-iodoamphetamine ([123I]IMP) scintigraphy and nonmotor symptoms in new-onset Lewy body disease (Parkinson’s disease and dementia with Lewy bodies [DLB]). Material and methods: Twenty-four patients diagnosed with new-onset Parkinson’s disease or DLB underwent [123I]IMP CBF scintigraphy at St. Marianna Medical University Hospital between January 1, 2010, and March 30, 2018. The reductions in CBF in various brain regions were analyzed using the three-dimensional stereotactic surface projection method and were compared to standard database values, yielding extent values (%). The extent values were evaluated in relation to the presence/absence of motor or nonmotor symptoms such as visual hallucinations, auditory hallucinations, delirium, depression, delusions, and dementia. Results: The extent value was 100% in the angular, supramarginal, and lingual gyri; 95% in the orbital gyri; and 92.6% in the fusiform gyri. The extent value in patients without hallucinations and those with visual hallucinations was 41.2% and 54.3%, respectively, in the frontal lobe (p = 0.02) and 33.3% and 51.0%, respectively, in the medial prefrontal gyri (p = 0.02). Age-adjusted multivariate analysis showed that extent values in the frontal lobe were associated with visual hallucinations (odds ratio: 1.09, 95% confidence interval 1.00–1.18, p = 0.04). Conclusions: The above results show that the CBF is reduced in several areas of the cerebral cortex and suggest an association between reduced blood flow in the frontal lobe and the appearance of visual hallucinations in patients with new-onset DLB.

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Keywords

hallucinations; dementia with Lewy bodies; radionuclide imaging

About this article
Title

Relationship between cerebral blood flow reduction patterns on scintigraphy and nonmotor symptoms in new-onset Lewy body disease

Journal

Nuclear Medicine Review

Issue

Vol 25, No 1 (2022)

Article type

Research paper

Pages

18-24

Published online

2022-01-31

Page views

5803

Article views/downloads

740

DOI

10.5603/NMR.a2022.0005

Pubmed

35137933

Bibliographic record

Nucl. Med. Rev 2022;25(1):18-24.

Keywords

hallucinations
dementia with Lewy bodies
radionuclide imaging

Authors

Yukinori Okada
Makoto Shiraishi
Koji Hori
Keiichro Yamaguchi
Yasuhiro Hasegawa

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