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Detection of brown tumors by [18F]F-choline PET/CT performed in a patient with secondary hyperparathyroidism
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Affiliations- Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Croatia
- School of Medicine, University of Zagreb, Croatia
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Abstract
Brown tumours are rare bone lesions occurring in patients with severe hyperparathyroidism (HPT) because of increased osteoclastic activity due to high levels of parathyroid hormone (PTH). We report the case of 30-year-old woman with secondary hyperparathyroidism due to severe chronic kidney diseases who underwent [18F]F-choline PET/CT scan for localization of the hyperfunctioning parathyroid gland before surgical treatment. [18F]F-choline PET/CT scan showed increased choline uptake in the lower left parathyroid gland and in multiple bone lytic lesions. Multiple focal choline uptake in bone corresponded to brown tumours — fibrous osteitis cystica.
Abstract
Brown tumours are rare bone lesions occurring in patients with severe hyperparathyroidism (HPT) because of increased osteoclastic activity due to high levels of parathyroid hormone (PTH). We report the case of 30-year-old woman with secondary hyperparathyroidism due to severe chronic kidney diseases who underwent [18F]F-choline PET/CT scan for localization of the hyperfunctioning parathyroid gland before surgical treatment. [18F]F-choline PET/CT scan showed increased choline uptake in the lower left parathyroid gland and in multiple bone lytic lesions. Multiple focal choline uptake in bone corresponded to brown tumours — fibrous osteitis cystica.
Keywords
[18F]F-choline PET/CT; brown tumours; fibrous osteitis cystica; hyperparathyroidism
About this articleTitle
Detection of brown tumors by [18F]F-choline PET/CT performed in a patient with secondary hyperparathyroidism
Journal
Issue
Vol 26 (2023): Continuous Publishing
Article type
Clinical vignette
Pages
49-51
Published online
2023-02-16
Page views
3020
Article views/downloads
503
DOI
Pubmed
Bibliographic record
Nucl. Med. Rev 2023;26:49-51.
Keywords
[18F]F-choline PET/CT
brown tumours
fibrous osteitis cystica
hyperparathyroidism
Authors
Ivan Rogic
Drazen Huic
References (8)- Muppidi V, Meegada SR, Rehman A. Secondary Hyperparathyroidism. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2022 Jan.
- Messina L, Garipoli A, Giordano FM, et al. A patient with multiple brown tumors due to secondary hyperparathyroidism: A case report. Radiol Case Rep. 2021; 16(9): 2482–2486.
- Choi JuH, Kim KJ, Lee YeJ, et al. Primary hyperparathyroidism with extensive brown tumors and multiple fractures in a 20-year-old woman. Endocrinol Metab (Seoul). 2015; 30(4): 614–619.
- Di Daniele N, Condò S, Ferrannini M, et al. Brown tumour in a patient with secondary hyperparathyroidism resistant to medical therapy: case report on successful treatment after subtotal parathyroidectomy. Int J Endocrinol. 2009: 827652.
- Treglia G, Piccardo A, Imperiale A, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019; 46(3): 751–765.
- Zanglis A, Andreopoulos D, Zissimopoulos A, et al. Multiple brown tumors with Tc-99m MDP superscan appearance and negative Tc-99m MIBI uptake. Clin Nucl Med. 2006; 31(10): 640–643.
- Zhang-Yin J, Gaujoux S, Delbot T, et al. 18F-Fluorocholine PET/CT imaging of brown tumors in a patient with severe primary hyperparathyroidism. Clin Nucl Med. 2019; 44(12): 971–974.
- Gedik GK, Ata O, Karabagli P, et al. Differential diagnosis between secondary and tertiary hyperparathyroidism in a case of a giant-cell and brown tumor containing mass. Findings by (99m)Tc-MDP, (18)F-FDG PET/CT and (99m)Tc-MIBI scans. Hell J Nucl Med. 2014; 17(3): 214–217.
