open access

Vol 22, No 1 (2019)
Original articles
Published online: 2019-01-31
Submitted: 2018-09-23
Accepted: 2019-01-18
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Myocardial ischemia in female patients with rheumatoid arthritis assessed with single photon emission tomography-myocardial perfusion imaging

Andreas Fotopoulos, Konstantinos Papadimitropoulos, Athanasios Papadopoulos, Labros Lakkas, Maria Spiliotopoulou, Tzimis - Dimitrios Kotrotsios, Konstantinos Pappas, Athanasios Notopoulos, Chrissa Sioka
DOI: 10.5603/NMR.2019.0001
·
Pubmed: 31482536
·
Nucl. Med. Rev 2019;22(1):8-13.

open access

Vol 22, No 1 (2019)
Original articles
Published online: 2019-01-31
Submitted: 2018-09-23
Accepted: 2019-01-18

Abstract

BACKGROUND: Non-specific cardiac symptoms in female patients with rheumatoid arthritis (RA) could indicate early cardiovascular disease.

MATERIALS AND METHODS: Myocardial perfusion imaging (MPI), with 99mTc tetrofosmin stress–rest single photon emission computer tomography (SPECT), in 13 RA female patients with atypical cardiac symptoms, was compared to 44 weight- and age-matched females with similar cardiac complaints (control group). Smoking, hypertension, diabetes mellitus, dyslipidemia, obesity and cardiac heredity were recorded and compared between the study and control group. MPI was assessed using 17 segment polar map and with a scale of 0 to 5 scoring.

RESULTS: Patients with RA demonstrated higher cardiovascular risk (46%) compared to control individuals (17%). In addition, patients with RA had more irreversible myocardial ischemic abnormalities in their MPI than the control group. Dyslipidemia and obesity was found more frequent in RA patients with MPI SSS ≥ 4.

CONCLUSION: RA patients with atypical cardiac complaints are at higher risk for cardiovascular disease; early detection and monitoring of this patient group could potentially reverse or successfully manage the consequences of the upcoming cardiovascular disease.

Abstract

BACKGROUND: Non-specific cardiac symptoms in female patients with rheumatoid arthritis (RA) could indicate early cardiovascular disease.

MATERIALS AND METHODS: Myocardial perfusion imaging (MPI), with 99mTc tetrofosmin stress–rest single photon emission computer tomography (SPECT), in 13 RA female patients with atypical cardiac symptoms, was compared to 44 weight- and age-matched females with similar cardiac complaints (control group). Smoking, hypertension, diabetes mellitus, dyslipidemia, obesity and cardiac heredity were recorded and compared between the study and control group. MPI was assessed using 17 segment polar map and with a scale of 0 to 5 scoring.

RESULTS: Patients with RA demonstrated higher cardiovascular risk (46%) compared to control individuals (17%). In addition, patients with RA had more irreversible myocardial ischemic abnormalities in their MPI than the control group. Dyslipidemia and obesity was found more frequent in RA patients with MPI SSS ≥ 4.

CONCLUSION: RA patients with atypical cardiac complaints are at higher risk for cardiovascular disease; early detection and monitoring of this patient group could potentially reverse or successfully manage the consequences of the upcoming cardiovascular disease.

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Keywords

myocardial perfusion imaging, myocardial ischemia, tetrofosmin, risk factors, females, rheumatoid arthritis

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About this article
Title

Myocardial ischemia in female patients with rheumatoid arthritis assessed with single photon emission tomography-myocardial perfusion imaging

Journal

Nuclear Medicine Review

Issue

Vol 22, No 1 (2019)

Pages

8-13

Published online

2019-01-31

DOI

10.5603/NMR.2019.0001

Pubmed

31482536

Bibliographic record

Nucl. Med. Rev 2019;22(1):8-13.

Keywords

myocardial perfusion imaging
myocardial ischemia
tetrofosmin
risk factors
females
rheumatoid arthritis

Authors

Andreas Fotopoulos
Konstantinos Papadimitropoulos
Athanasios Papadopoulos
Labros Lakkas
Maria Spiliotopoulou
Tzimis - Dimitrios Kotrotsios
Konstantinos Pappas
Athanasios Notopoulos
Chrissa Sioka

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