open access

Vol 21, No 2 (2018)
Clinical vignette
Published online: 2018-05-23
Submitted: 2017-12-27
Accepted: 2018-03-14
Get Citation

Striatal hypermetabolism in a case of IgG4-related disease

Abdelhamid Biyi, Omar Ait Sahel, Abderrahim Mejjad, Yasser Benameur, Salah Nabih Oueriagli, Abderrahim Doudouh
DOI: 10.5603/NMR.2018.0018
·
Nucl. Med. Rev 2018;21(2):109-110.

open access

Vol 21, No 2 (2018)
Clinical vignette
Published online: 2018-05-23
Submitted: 2017-12-27
Accepted: 2018-03-14

Abstract

A 77 years-old man with lung and bone involvement of proven IgG4-related disease complained of tree month’s memory deficits. Brain MRI was normal. 18F-FDG whole body PET/CT showed in addition to the bone lesions, a marked symmetrical striatal hypermetabolism in contrast with cortical hypometabolism. Despite steroid treatment, the patient’s clinical status declined rapidly and he died two months later. Striatal hypermetabolism has been reported in autoimmune limbic encephalitis, but to the best of our knowledge, this is the first description in a case of IgG4-related disease.

Abstract

A 77 years-old man with lung and bone involvement of proven IgG4-related disease complained of tree month’s memory deficits. Brain MRI was normal. 18F-FDG whole body PET/CT showed in addition to the bone lesions, a marked symmetrical striatal hypermetabolism in contrast with cortical hypometabolism. Despite steroid treatment, the patient’s clinical status declined rapidly and he died two months later. Striatal hypermetabolism has been reported in autoimmune limbic encephalitis, but to the best of our knowledge, this is the first description in a case of IgG4-related disease.

Get Citation

Keywords

IgG4-related disease, striatal hypermetabolism, limbic encephalitis, 18F-FDG PET/CT

About this article
Title

Striatal hypermetabolism in a case of IgG4-related disease

Journal

Nuclear Medicine Review

Issue

Vol 21, No 2 (2018)

Pages

109-110

Published online

2018-05-23

DOI

10.5603/NMR.2018.0018

Bibliographic record

Nucl. Med. Rev 2018;21(2):109-110.

Keywords

IgG4-related disease
striatal hypermetabolism
limbic encephalitis
18F-FDG PET/CT

Authors

Abdelhamid Biyi
Omar Ait Sahel
Abderrahim Mejjad
Yasser Benameur
Salah Nabih Oueriagli
Abderrahim Doudouh

References (3)
  1. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003; 38(10): 982–984.
  2. Heine J, Prüss H, Bartsch T, et al. Imaging of autoimmune encephalitis--Relevance for clinical practice and hippocampal function. Neuroscience. 2015; 309: 68–83.
  3. Rey C, Koric L, Guedj E, et al. Striatal hypermetabolism in limbic encephalitis. J Neurol. 2012; 259(6): 1106–1110.

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