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Striatal hypermetabolism in a case of IgG4-related disease
Affiliations- Mohammed V University of Rabat, Department of Nuclear Medicine, Mohammed V Military Teaching Hospital, Mohammed V University of Rabat, Rabat, Morocco
open access
Abstract
A 77 years-old man with lung and bone involvement of proven IgG4-related disease complained of tree month’s memory deficits. Brain MRI was normal. 18F-FDG whole body PET/CT showed in addition to the bone lesions, a marked symmetrical striatal hypermetabolism in contrast with cortical hypometabolism. Despite steroid treatment, the patient’s clinical status declined rapidly and he died two months later. Striatal hypermetabolism has been reported in autoimmune limbic encephalitis, but to the best of our knowledge, this is the first description in a case of IgG4-related disease.
Abstract
A 77 years-old man with lung and bone involvement of proven IgG4-related disease complained of tree month’s memory deficits. Brain MRI was normal. 18F-FDG whole body PET/CT showed in addition to the bone lesions, a marked symmetrical striatal hypermetabolism in contrast with cortical hypometabolism. Despite steroid treatment, the patient’s clinical status declined rapidly and he died two months later. Striatal hypermetabolism has been reported in autoimmune limbic encephalitis, but to the best of our knowledge, this is the first description in a case of IgG4-related disease.
Keywords
IgG4-related disease, striatal hypermetabolism, limbic encephalitis, 18F-FDG PET/CT
About this articleTitle
Striatal hypermetabolism in a case of IgG4-related disease
Journal
Issue
Article type
Clinical vignette
Pages
109-110
Published online
2018-05-23
Page views
2299
Article views/downloads
771
DOI
Bibliographic record
Nucl. Med. Rev 2018;21(2):109-110.
Keywords
IgG4-related disease
striatal hypermetabolism
limbic encephalitis
18F-FDG PET/CT
Authors
Abdelhamid Biyi
Omar Ait Sahel
Abderrahim Mejjad
Yasser Benameur
Salah Nabih Oueriagli
Abderrahim Doudouh
References (3)- Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003; 38(10): 982–984.
- Heine J, Prüss H, Bartsch T, et al. Imaging of autoimmune encephalitis--Relevance for clinical practice and hippocampal function. Neuroscience. 2015; 309: 68–83.
- Rey C, Koric L, Guedj E, et al. Striatal hypermetabolism in limbic encephalitis. J Neurol. 2012; 259(6): 1106–1110.
