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99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death
open access
Abstract
This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.
Abstract
This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.
Keywords
brain death; perfusion imaging, HMPAO, SPECT, SPECT/CT
About this articleTitle
99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death
Journal
Issue
Article type
Case report
Pages
22-23
Published online
2016-10-14
Page views
1530
Article views/downloads
2133
DOI
Pubmed
Keywords
brain death
perfusion imaging
HMPAO
SPECT
SPECT/CT
Authors
Thorsten Derlin
Desiree Weiberg
