open access

Vol 26 (2023): Continuous Publishing
Clinical vignette
Submitted: 2023-08-26
Accepted: 2023-09-10
Published online: 2023-11-22
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Radioiodine scan revealing a primary lung adenocarcinoma in a patient with differentiated thyroid carcinoma

Majdouline Bel Lakhdar1, Sabrine Derqaoui2, Ouafae Boumaaza1, Jamila Rahali1, Ayat Mouaden1, Hasnae Guerrouj1, Imad Ghfir1, Nouzha Ben Rais1
·
Nucl. Med. Rev 2023;26:130-133.
Affiliations
  1. Deparment of Nuclear Medicine, Academic Hospital Ibn Sina, Faculty of Medicine and Pharmacy, University Mohammed V, Souissi, Rabat, Morocco
  2. Deparment of Anatomical Pathology, Academic Hospital Ibn Sina, Faculty of Medicine and Pharmacy, University Mohammed V, Souissi, Rabat, Morocco

open access

Vol 26 (2023): Continuous Publishing
Clinical vignette
Submitted: 2023-08-26
Accepted: 2023-09-10
Published online: 2023-11-22

Abstract

The radioiodine scan is a non-invasive imaging modality that allows for the visualization of functional thyroid tissue, as well as the detection of thyroid cancer remnants and metastases. However, it is important to note that radioiodine uptake is not exclusive to thyroid tissue and can lead to false-positive results if unexpected uptake occurs in non-thyroidal tissue. Herein, we present a case of a patient diagnosed with thyroid carcinoma, whose radioiodine scan demonstrated increased uptake in the thorax, corresponding to a lung carcinoma.

Abstract

The radioiodine scan is a non-invasive imaging modality that allows for the visualization of functional thyroid tissue, as well as the detection of thyroid cancer remnants and metastases. However, it is important to note that radioiodine uptake is not exclusive to thyroid tissue and can lead to false-positive results if unexpected uptake occurs in non-thyroidal tissue. Herein, we present a case of a patient diagnosed with thyroid carcinoma, whose radioiodine scan demonstrated increased uptake in the thorax, corresponding to a lung carcinoma.

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Keywords

false positive; radioiodine; lung cancer; thyroid carcinoma; multiple primary malignant neoplasms

About this article
Title

Radioiodine scan revealing a primary lung adenocarcinoma in a patient with differentiated thyroid carcinoma

Journal

Nuclear Medicine Review

Issue

Vol 26 (2023): Continuous Publishing

Article type

Clinical vignette

Pages

130-133

Published online

2023-11-22

Page views

371

Article views/downloads

194

DOI

10.5603/nmr.97128

Bibliographic record

Nucl. Med. Rev 2023;26:130-133.

Keywords

false positive
radioiodine
lung cancer
thyroid carcinoma
multiple primary malignant neoplasms

Authors

Majdouline Bel Lakhdar
Sabrine Derqaoui
Ouafae Boumaaza
Jamila Rahali
Ayat Mouaden
Hasnae Guerrouj
Imad Ghfir
Nouzha Ben Rais

References (14)
  1. Triggiani V, Giagulli VA, Iovino M, et al. False positive diagnosis on (131)iodine whole-body scintigraphy of differentiated thyroid cancers. Endocrine. 2016; 53(3): 626–635.
  2. Durante C, Haddy N, Baudin E, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab. 2006; 91(8): 2892–2899.
  3. Herrmann C, Cerny T, Savidan A, et al. Cancer survivors in Switzerland: a rapidly growing population to care for. BMC Cancer. 2013(13): 287.
  4. Vogt A, Schmid S, Heinimann K, et al. Multiple primary tumours: challenges and approaches, a review. ESMO Open. 2017; 2(2): e000172.
  5. Babacan NA, Aksoy S, Cetin B, et al. Multiple primary malignant neoplasms: multi-center results from Turkey. J BUON. 2012; 17(4): 770–775.
  6. Liu Z, Liu C, Guo W, et al. Clinical analysis of 152 cases of multiple primary malignant tumors in 15,398 patients with malignant tumors. PLoS One. 2015; 10(5): e0125754.
  7. Frödin JE, Ericsson J, Barlow L. Multiple primary malignant tumors in a national cancer registry — reliability of reporting. Acta Oncol. 1997; 36(5): 465–469.
  8. Omür O, Ozcan Z, Yazici B, et al. Multiple primary tumors in differentiated thyroid carcinoma and relationship to thyroid cancer outcome. Endocr J. 2008; 55(2): 365–372.
  9. Ronckers CM, McCarron P, Ron E. Thyroid cancer and multiple primary tumors in the SEER cancer registries. Int J Cancer. 2005; 117(2): 281–288.
  10. Oh JR, Ahn BC. False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am J Nucl Med Mol Imaging. 2012; 2(3): 362–385.
  11. Knut and Alice Wallenberg foundation. The Human Protein Atlas. Expression of SLC5A5 in lung cancer. https://www.proteinatlas.org/ENSG00000105641-%20SLC5A5/pathology/Lung+cancer (8.09.2020).
  12. Kang DoY, Lee HW, Choi PJ, et al. Sodium/iodide symporter expression in primary lung cancer and comparison with glucose transporter 1 expression. Pathol Int. 2009; 59(2): 73–79.
  13. Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature. 2008; 454(7203): 436–444.
  14. Lu YL, Chen ST, Ho TY, et al. Primary lung cancer with radioiodine avidity: A thyroid cancer cohort study. World J Clin Cases. 2021; 9(1): 71–80.

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