open access

Vol 19, Supp. B (2016)
Case Report
Published online: 2016-10-14
Submitted: 2015-12-27
Accepted: 2016-08-18
Get Citation

99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death

Thorsten Derlin, Desiree Weiberg
DOI: 10.5603/NMR.2016.0033
·
Pubmed: 27900758

open access

Vol 19, Supp. B (2016)
Case Report
Published online: 2016-10-14
Submitted: 2015-12-27
Accepted: 2016-08-18

Abstract

This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.

Abstract

This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.

Get Citation

Keywords

brain death; perfusion imaging, HMPAO, SPECT, SPECT/CT

About this article
Title

99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death

Journal

Nuclear Medicine Review

Issue

Vol 19, Supp. B (2016)

Pages

22-23

Published online

2016-10-14

DOI

10.5603/NMR.2016.0033

Pubmed

27900758

Keywords

brain death
perfusion imaging
HMPAO
SPECT
SPECT/CT

Authors

Thorsten Derlin
Desiree Weiberg

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