open access
Bone scan in metabolic bone diseases. Review
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Abstract
that tend to present a generalized involvement of the whole
skeleton. The disorders are mostly related to increased bone
turnover and increased uptake of radiolabelled diphosphonate.
Skeletal uptake of 99mTc-labelled diphosphonate depends primarily
upon osteoblastic activity, and to a lesser extent, skeletal
vascularity. A bone scan image therefore presents a functional
display of total skeletal metabolism and has valuable role to
play in the assessment of patients with metabolic bone disorders.
However, the bone scan appearances in metabolic bone
disease are often non-specific, and their recognition depends
on increased tracer uptake throughout the whole skeleton. It
is the presence of local lesions, as in metastatic disease, that
makes a bone scan appearance obviously abnormal. In the
early stages, there will be difficulty in evaluating the bone scans
from many patients with metabolic bone disease. However, in
the more severe cases scan appearances can be quite striking
and virtually diagnostic.
Abstract
that tend to present a generalized involvement of the whole
skeleton. The disorders are mostly related to increased bone
turnover and increased uptake of radiolabelled diphosphonate.
Skeletal uptake of 99mTc-labelled diphosphonate depends primarily
upon osteoblastic activity, and to a lesser extent, skeletal
vascularity. A bone scan image therefore presents a functional
display of total skeletal metabolism and has valuable role to
play in the assessment of patients with metabolic bone disorders.
However, the bone scan appearances in metabolic bone
disease are often non-specific, and their recognition depends
on increased tracer uptake throughout the whole skeleton. It
is the presence of local lesions, as in metastatic disease, that
makes a bone scan appearance obviously abnormal. In the
early stages, there will be difficulty in evaluating the bone scans
from many patients with metabolic bone disease. However, in
the more severe cases scan appearances can be quite striking
and virtually diagnostic.
Keywords
metabolic bone disease, superscan, focal uptake, 99mTc diphosphonate
Title
Bone scan in metabolic bone diseases. Review
Journal
Issue
Article type
Review paper
Pages
124-131
Published online
2012-08-25
Page views
2391
Article views/downloads
27500
Bibliographic record
Nucl. Med. Rev 2012;15(2):124-131.
Keywords
metabolic bone disease
superscan
focal uptake
99mTc diphosphonate
Authors
Saeid Abdelrazek
Piotr Szumowski
Franciszek Rogowski
Agnieszka Kociura-Sawicka
Małgorzata Mojsak
Małgorzata Szorc