open access

Vol 15, No 2 (2012)
Review paper
Published online: 2012-08-25
Submitted: 2012-08-31
Accepted: 2012-08-31
Get Citation

Bone scan in metabolic bone diseases. Review

Saeid Abdelrazek, Piotr Szumowski, Franciszek Rogowski, Agnieszka Kociura-Sawicka, Małgorzata Mojsak, Małgorzata Szorc
Nucl. Med. Rev 2012;15(2):124-131.

open access

Vol 15, No 2 (2012)
Reviews
Published online: 2012-08-25
Submitted: 2012-08-31
Accepted: 2012-08-31

Abstract

Metabolic bone disease encompasses a number of disorders
that tend to present a generalized involvement of the whole
skeleton. The disorders are mostly related to increased bone
turnover and increased uptake of radiolabelled diphosphonate.
Skeletal uptake of 99mTc-labelled diphosphonate depends primarily
upon osteoblastic activity, and to a lesser extent, skeletal
vascularity. A bone scan image therefore presents a functional
display of total skeletal metabolism and has valuable role to
play in the assessment of patients with metabolic bone disorders.
However, the bone scan appearances in metabolic bone
disease are often non-specific, and their recognition depends
on increased tracer uptake throughout the whole skeleton. It
is the presence of local lesions, as in metastatic disease, that
makes a bone scan appearance obviously abnormal. In the
early stages, there will be difficulty in evaluating the bone scans
from many patients with metabolic bone disease. However, in
the more severe cases scan appearances can be quite striking
and virtually diagnostic.

Abstract

Metabolic bone disease encompasses a number of disorders
that tend to present a generalized involvement of the whole
skeleton. The disorders are mostly related to increased bone
turnover and increased uptake of radiolabelled diphosphonate.
Skeletal uptake of 99mTc-labelled diphosphonate depends primarily
upon osteoblastic activity, and to a lesser extent, skeletal
vascularity. A bone scan image therefore presents a functional
display of total skeletal metabolism and has valuable role to
play in the assessment of patients with metabolic bone disorders.
However, the bone scan appearances in metabolic bone
disease are often non-specific, and their recognition depends
on increased tracer uptake throughout the whole skeleton. It
is the presence of local lesions, as in metastatic disease, that
makes a bone scan appearance obviously abnormal. In the
early stages, there will be difficulty in evaluating the bone scans
from many patients with metabolic bone disease. However, in
the more severe cases scan appearances can be quite striking
and virtually diagnostic.
Get Citation

Keywords

metabolic bone disease, superscan, focal uptake, 99mTc diphosphonate

About this article
Title

Bone scan in metabolic bone diseases. Review

Journal

Nuclear Medicine Review

Issue

Vol 15, No 2 (2012)

Article type

Review paper

Pages

124-131

Published online

2012-08-25

Bibliographic record

Nucl. Med. Rev 2012;15(2):124-131.

Keywords

metabolic bone disease
superscan
focal uptake
99mTc diphosphonate

Authors

Saeid Abdelrazek
Piotr Szumowski
Franciszek Rogowski
Agnieszka Kociura-Sawicka
Małgorzata Mojsak
Małgorzata Szorc

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