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open access

Vol 15, No 1 (2012)
Review paper
Submitted: 2012-04-26
Accepted: 2012-04-26
Published online: 2012-04-24
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Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment)

Małgorzata Kobylecka, Joanna Mączewska, Katarzyna Fronczewska-Wieniawska, Tomasz Mazurek, Maria Teresa Płazińska, Leszek Królicki
Nucl. Med. Rev 2012;15(1):52-60.

open access

Vol 15, No 1 (2012)
Reviews
Submitted: 2012-04-26
Accepted: 2012-04-26
Published online: 2012-04-24

Abstract

Accurate identification of viable myocardium is crucial in patientqualification for medical or surgical treatment. Only personswith confirmed cardiac viability will benefit from revascularizationprocedures. It is also well known, that the amount of viablemyocardium assessed preoperatively is the best indicator oflong term cardiac event free survival after cardiac intervention.There are several diagnostic approaches used in current clinicalpractice for assessment of myocardial viability. Analysis ofwall thickness or myocardial contraction, evaluation of cardiacperfusion or metabolism can be assessed using followingmodalities: Echocardiography, Cardiac Molecular Imagingtechniques (PET, SPECT), Cardiovascular MR or CardiovascularCT. The article describes the methods and problems ofviability assessment in 18FDG PET study. PET imaging hasproved its accuracy and reproducibility for myocardial ischemiaand viability assessment. However this unique in its ability forshowing the particular substrate metabolism technique has unfortunately some disadvantages: currently achieved PETresolution is 0.4 cm. However the combined devices multislicecomputed tomography scanners with PET (PET/CT) are nowwidely used in clinical practice. This combination allows forwider morphologic assessments: coronary calcium scoring andnon-invasive coronary angiography may be added to myocardialperfusion/metabolic imaging if necessary.

Abstract

Accurate identification of viable myocardium is crucial in patientqualification for medical or surgical treatment. Only personswith confirmed cardiac viability will benefit from revascularizationprocedures. It is also well known, that the amount of viablemyocardium assessed preoperatively is the best indicator oflong term cardiac event free survival after cardiac intervention.There are several diagnostic approaches used in current clinicalpractice for assessment of myocardial viability. Analysis ofwall thickness or myocardial contraction, evaluation of cardiacperfusion or metabolism can be assessed using followingmodalities: Echocardiography, Cardiac Molecular Imagingtechniques (PET, SPECT), Cardiovascular MR or CardiovascularCT. The article describes the methods and problems ofviability assessment in 18FDG PET study. PET imaging hasproved its accuracy and reproducibility for myocardial ischemiaand viability assessment. However this unique in its ability forshowing the particular substrate metabolism technique has unfortunately some disadvantages: currently achieved PETresolution is 0.4 cm. However the combined devices multislicecomputed tomography scanners with PET (PET/CT) are nowwidely used in clinical practice. This combination allows forwider morphologic assessments: coronary calcium scoring andnon-invasive coronary angiography may be added to myocardialperfusion/metabolic imaging if necessary.

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Keywords

cardiac viability, hibernation, perfusion, cardiac imaging, viability imaging, SPECT, MIBI-SPECT, PET, 18FDG-PET, PET/CT, perfusion/metabolic mismatch

About this article
Title

Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment)

Journal

Nuclear Medicine Review

Issue

Vol 15, No 1 (2012)

Article type

Review paper

Pages

52-60

Published online

2012-04-24

Page views

2347

Article views/downloads

4551

Bibliographic record

Nucl. Med. Rev 2012;15(1):52-60.

Keywords

cardiac viability
hibernation
perfusion
cardiac imaging
viability imaging
SPECT
MIBI-SPECT
PET
18FDG-PET
PET/CT
perfusion/metabolic mismatch

Authors

Małgorzata Kobylecka
Joanna Mączewska
Katarzyna Fronczewska-Wieniawska
Tomasz Mazurek
Maria Teresa Płazińska
Leszek Królicki

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