99m Tc-Ethylenedicysteine (99mTc-EC) Renal Clearance Determination Error for the Multiple- and Single-Sample Methods
Nucl. Med. Rev 1998;1(1):33-40.
Vol 1, No 1 (1998)
Submitted: 2012-01-23
Published online: 2000-02-10
Abstract
BACKGROUND: The aim of this work has been to assay determination error
values for the clearance determined by singel- and multi-sample method and to
compare the error values obtained for both mathods.
METHODS: The assay has been conducted by two independent methods
(Monte Carlo simulation, total differential)
RESULTS: The results indicate that the relative root mean square error
of the clearance determination by multisample method is practically constant
above CI calues 150 ml/min and amounts to ab ?3-4%. For values below 150 ml/min
the error increases and reaches ?12% at CI=70 ml/min. The one sample method is
less accurate and error oncreases from ?(8-9)% 550 ml/min to ? 25% at 70 ml/min.
Moreover, for the multisample method the error estimated from total differential
exceeds that obtained from Monte Carlo produced by factory of 3 to 4. For the
one sample clearance determination both error estimates yield simular results.
In both methods of clearance determination inaccurate pipetting makes a dominant
contribution to the overall error.
CONCLUSIONS: Form monitiring of patients' condition the multisample
method should be employed. The use of one sample method should be limited to
screeninig tests and for obtainig additional information, supplenemting the
dynamic scintigraphic studies
Abstract
BACKGROUND: The aim of this work has been to assay determination error
values for the clearance determined by singel- and multi-sample method and to
compare the error values obtained for both mathods.
METHODS: The assay has been conducted by two independent methods
(Monte Carlo simulation, total differential)
RESULTS: The results indicate that the relative root mean square error
of the clearance determination by multisample method is practically constant
above CI calues 150 ml/min and amounts to ab ?3-4%. For values below 150 ml/min
the error increases and reaches ?12% at CI=70 ml/min. The one sample method is
less accurate and error oncreases from ?(8-9)% 550 ml/min to ? 25% at 70 ml/min.
Moreover, for the multisample method the error estimated from total differential
exceeds that obtained from Monte Carlo produced by factory of 3 to 4. For the
one sample clearance determination both error estimates yield simular results.
In both methods of clearance determination inaccurate pipetting makes a dominant
contribution to the overall error.
CONCLUSIONS: Form monitiring of patients' condition the multisample
method should be employed. The use of one sample method should be limited to
screeninig tests and for obtainig additional information, supplenemting the
dynamic scintigraphic studies
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99m Tc-Ethylenedicysteine (99mTc-EC) Renal Clearance Determination Error for the Multiple- and Single-Sample Methods
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33-40
Published online
2000-02-10
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Nucl. Med. Rev 1998;1(1):33-40.
Authors
Marian J. Surma
