Vol 1, No 1 (1998)
Research paper
Published online: 2000-02-10
Verification of 99mTc-Ethylenedicysteine (99mTc-EC) distribution model in the organism
Nucl. Med. Rev 1998;1(1):29-32.
Abstract
Background: The aim of the present study was an attempt to verify the systemic distribution of 99mTC-ethylenedicysteine by means of the open two-compartment model.
Methods: In order to accomplish this, 99mTc-EC clearance was determined in 21 patients as: two-compartmental model-based plasma clearance, and a urinary clearance, i.e. utilising the 99mTc-EC activity excreted with urine during a finite time interval.
Results: There is a close correlation (r = 0.97) between the clearance values determined according to these two methods, and the rectilinear orthogonal correlation equation assumes a C1ECu = 1.03656C1ECp - 18.064 form. The slope of the line does not differ significantly from unity. The shift of the correlation line along the X-axis indicates a minor excretion of the radiopharmaceutical also by routes different from the urinary tract, e.g. with the bile.
Conlusions: The performed comparison of the clearance values has proved that distribution of 99mTc-EC in the organism is consistent with the open two-compartment model.
Methods: In order to accomplish this, 99mTc-EC clearance was determined in 21 patients as: two-compartmental model-based plasma clearance, and a urinary clearance, i.e. utilising the 99mTc-EC activity excreted with urine during a finite time interval.
Results: There is a close correlation (r = 0.97) between the clearance values determined according to these two methods, and the rectilinear orthogonal correlation equation assumes a C1ECu = 1.03656C1ECp - 18.064 form. The slope of the line does not differ significantly from unity. The shift of the correlation line along the X-axis indicates a minor excretion of the radiopharmaceutical also by routes different from the urinary tract, e.g. with the bile.
Conlusions: The performed comparison of the clearance values has proved that distribution of 99mTc-EC in the organism is consistent with the open two-compartment model.
Keywords: 99mTc-EC kidney clearance99mTc-EC distribution model
