Vol 1, No 1 (1998)
Original articles
Published online: 2000-02-10
Submitted: 2012-01-23
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Cerebral blood flow assessed by brain SPECT with 99mTc-HMPAO utilising the acetazolamide test in systemic lupus erythematosus

Piotr Lass, Mirosław Koseda, Grzegorz Romanowicz, Janina Mechlińska, Zyta Banecka, Monika Góra, Marek Hebanowski, Ewa Stępień, Piotr Łyczak
Nucl. Med. Rev 1998;1(1):20-24.
Vol 1, No 1 (1998)
Original articles
Published online: 2000-02-10
Submitted: 2012-01-23

Abstract

Background: Cerebrovascular diseases are one of the most important complications of systemic lupus erythematosus (SLE). The diagnostic imaging of neuropsychiatric SLE complications presents many problems. This study was undertaken to investigate cerebral blood flow char s and its reactivity to hypercapnia by means of acetazolamide test in SLE patients.
Methods: Brain SPELT studies using 99mTc-HMPAO were performed in 50 patients with SLE. Acetazolamide test was performed in 35 patients 3 days after the baseline study by means of repetitive scanning 20 min after i.v. injection of 1.0 g of acetazolamide.
Results: Significant interhemispheric hypoperfusion areas were shown in 76.3% of all patients, 83.8% symptomatic and 63.1 % asymptomatic. Patients with antiphospholipid syndrome showed multifocal perfusion deficits. The reaction of cerebral perfusion to acetazolamide was heterogenous and showed increase, decrease, no change or mixed reaction of baseline-study-found focal hypoperfusion. Acetazolamide test revealed hypoperfusion in two patients with normal baseline study. MRI scanning revealed cerebral lesions in 41 % of patients.
Conclusions: CBF asymmetries in symptomatic and asymptomatic patients with SLE are frequent. Regional CBF alterations seem to be different in patients with and without antiphospholipid syndrome. The part of the patients with SLE shows no or paradoxically inversed reaction to acetazolamide.

Abstract

Background: Cerebrovascular diseases are one of the most important complications of systemic lupus erythematosus (SLE). The diagnostic imaging of neuropsychiatric SLE complications presents many problems. This study was undertaken to investigate cerebral blood flow char s and its reactivity to hypercapnia by means of acetazolamide test in SLE patients.
Methods: Brain SPELT studies using 99mTc-HMPAO were performed in 50 patients with SLE. Acetazolamide test was performed in 35 patients 3 days after the baseline study by means of repetitive scanning 20 min after i.v. injection of 1.0 g of acetazolamide.
Results: Significant interhemispheric hypoperfusion areas were shown in 76.3% of all patients, 83.8% symptomatic and 63.1 % asymptomatic. Patients with antiphospholipid syndrome showed multifocal perfusion deficits. The reaction of cerebral perfusion to acetazolamide was heterogenous and showed increase, decrease, no change or mixed reaction of baseline-study-found focal hypoperfusion. Acetazolamide test revealed hypoperfusion in two patients with normal baseline study. MRI scanning revealed cerebral lesions in 41 % of patients.
Conclusions: CBF asymmetries in symptomatic and asymptomatic patients with SLE are frequent. Regional CBF alterations seem to be different in patients with and without antiphospholipid syndrome. The part of the patients with SLE shows no or paradoxically inversed reaction to acetazolamide.
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Keywords

acetazolamide; connective tissue diseases; systemic lupus erythematosus; technetium-99m-HMPAO; single photon emission computed tomography

About this article
Title

Cerebral blood flow assessed by brain SPECT with 99mTc-HMPAO utilising the acetazolamide test in systemic lupus erythematosus

Journal

Nuclear Medicine Review

Issue

Vol 1, No 1 (1998)

Pages

20-24

Published online

2000-02-10

Bibliographic record

Nucl. Med. Rev 1998;1(1):20-24.

Keywords

acetazolamide
connective tissue diseases
systemic lupus erythematosus
technetium-99m-HMPAO
single photon emission computed tomography

Authors

Piotr Lass
Mirosław Koseda
Grzegorz Romanowicz
Janina Mechlińska
Zyta Banecka
Monika Góra
Marek Hebanowski
Ewa Stępień
Piotr Łyczak

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