Vol 3, No 1 (2000)
Published online: 2000-02-25
Radionuclide voiding pattern in children with unstable bladder
Nucl. Med. Rev 2000;3(1):53-56.
Abstract
BACKGROUND: The purpose of this study was to investigate bladder function parameters by means of quantitative radionuclide cystography (QRC) in anxious, irritable children with unstable bladder.
METHODS: Quantitative radionuclide cystography was performed in 18 children aged between 8 and 12 years, without evidence of neurologic and nephrourologic disorders. Findings were compared with those obtained in 10 healthy children aged between 7 and 10 years. The dynamics of the bladder emptying were studied after intravenous injection of 37 MBq/10 kg b.w. 99mTc-diethylenetriaminepentaacetic acid (DTPA) in the posterior views. Images of 90 frames every 2 sec. were stored in the 64x64 computer matrix during voiding. The patients voided into a container and the volumes were measured.
RESULTS: The parameters evaluated were: functional bladder capacity (ml) - FBC, expected bladder capacity (ml) - EBC, percentage of EBC (%), voided urine volume (ml) - VV, residual urine (ml) - RU, voiding time (sec) - VT, average flow rate (ml/sec) - AFR and peak flow rate (ml/sec) - PFR. There was a statistically significant difference between controls and children with unstable bladder in the following parameters: FBC 288 ± 33 vs. 244 ± 27 ml (p < 0.001), % of EBC 99 ± 6 vs. 82 ± 6% (p < 0.0001), VV 265 ± 37 vs. 202 ± 35 ml (p < 0.0001), RU 22 ± 11 vs. 48 ± 19 ml (p < 0.007), AFR 13 ± 5 ml/sec vs. 9 ± 4 ml/sec. (p < 0.01) and PFR 19 ± 2 vs. 13 ± 3 ml/s (p < 0.0001), respectively. The VT obtained from the control group of 23 ± 9 s did not differ significantly from the value of children with unstable bladder of 28 ± 14 s.
CONCLUSION: The results show that quantitative radionuclide cystography is a simple, noninvasive method, which allows a good separation of patients with unstable bladder from the children with normal voiding pattern.
METHODS: Quantitative radionuclide cystography was performed in 18 children aged between 8 and 12 years, without evidence of neurologic and nephrourologic disorders. Findings were compared with those obtained in 10 healthy children aged between 7 and 10 years. The dynamics of the bladder emptying were studied after intravenous injection of 37 MBq/10 kg b.w. 99mTc-diethylenetriaminepentaacetic acid (DTPA) in the posterior views. Images of 90 frames every 2 sec. were stored in the 64x64 computer matrix during voiding. The patients voided into a container and the volumes were measured.
RESULTS: The parameters evaluated were: functional bladder capacity (ml) - FBC, expected bladder capacity (ml) - EBC, percentage of EBC (%), voided urine volume (ml) - VV, residual urine (ml) - RU, voiding time (sec) - VT, average flow rate (ml/sec) - AFR and peak flow rate (ml/sec) - PFR. There was a statistically significant difference between controls and children with unstable bladder in the following parameters: FBC 288 ± 33 vs. 244 ± 27 ml (p < 0.001), % of EBC 99 ± 6 vs. 82 ± 6% (p < 0.0001), VV 265 ± 37 vs. 202 ± 35 ml (p < 0.0001), RU 22 ± 11 vs. 48 ± 19 ml (p < 0.007), AFR 13 ± 5 ml/sec vs. 9 ± 4 ml/sec. (p < 0.01) and PFR 19 ± 2 vs. 13 ± 3 ml/s (p < 0.0001), respectively. The VT obtained from the control group of 23 ± 9 s did not differ significantly from the value of children with unstable bladder of 28 ± 14 s.
CONCLUSION: The results show that quantitative radionuclide cystography is a simple, noninvasive method, which allows a good separation of patients with unstable bladder from the children with normal voiding pattern.
Keywords: childrenenuresisunstable bladdervoidingradionuclide cystographyurinary flow ratebladder emptying
