Hepatic plasma clearance of 99m Tc-HEPIDA as a diagnostic tool: Theoretical basis for a simplified determination

Abstract

The determination of hepatic plasma clearance of ^99m Tc-HEPI-DA is becoming a clinically attractive test. It is not necessary to perform always the determination using an extensive sampling of blood over the period of 0-90 min post injection of the radiopharmaceutical. For screening purposes a simplified method is adequate, even if less precise of the low values of the clearance. In this paper a theoretical basis has been presented for the development of such a simplified procedure, based on a?single plasma sample for determination of the hepatic and urinary clearance of ^99m Tc-HEPIDA.