open access

Vol 4, No 2 (2001)
Published online: 2001-07-23
Submitted: 2012-01-23
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Hepatic plasma clearance of 99m Tc-HEPIDA as a diagnostic tool: Theoretical basis for a simplified determination

Marian J. Surma
Nucl. Med. Rev 2001;4(2):83-88.

open access

Vol 4, No 2 (2001)
Published online: 2001-07-23
Submitted: 2012-01-23

Abstract

The determination of hepatic plasma clearance of 99m Tc-HEPI-DA is becoming a clinically attractive test. It is not necessary to perform always the determination using an extensive sampling of blood over the period of 0-90 min post injection of the radiopharmaceutical. For screening purposes a simplified method is adequate, even if less precise of the low values of the clearance. In this paper a theoretical basis has been presented for the development of such a simplified procedure, based on a?single plasma sample for determination of the hepatic and urinary clearance of 99m Tc-HEPIDA.

Abstract

The determination of hepatic plasma clearance of 99m Tc-HEPI-DA is becoming a clinically attractive test. It is not necessary to perform always the determination using an extensive sampling of blood over the period of 0-90 min post injection of the radiopharmaceutical. For screening purposes a simplified method is adequate, even if less precise of the low values of the clearance. In this paper a theoretical basis has been presented for the development of such a simplified procedure, based on a?single plasma sample for determination of the hepatic and urinary clearance of 99m Tc-HEPIDA.
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Keywords

Tc-HEPIDA: total plasma clearance; 99m Tc-HEPIDA hepatic and urinary clearance

About this article
Title

Hepatic plasma clearance of 99m Tc-HEPIDA as a diagnostic tool: Theoretical basis for a simplified determination

Journal

Nuclear Medicine Review

Issue

Vol 4, No 2 (2001)

Pages

83-88

Published online

2001-07-23

Bibliographic record

Nucl. Med. Rev 2001;4(2):83-88.

Keywords

Tc-HEPIDA: total plasma clearance
99m Tc-HEPIDA hepatic and urinary clearance

Authors

Marian J. Surma

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