open access

Vol 5, No 1 (2002)
Short communications
Published online: 2002-01-17
Submitted: 2012-01-23
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Cerebral blood flow SPECT imaging in right hemisphere-damaged patients with hemispatial neglect. A pilot study

Krzysztof Jodzio, Piotr Lass, Walenty Nyka, Dariusz Gąsecki, Tomasz Bandurski, Justyna Scheffler
Nucl. Med. Rev 2002;5(1):49-51.

open access

Vol 5, No 1 (2002)
Short communications
Published online: 2002-01-17
Submitted: 2012-01-23

Abstract

BACKGROUND: Hemispatial neglect is characterised as a failure by a brain-damaged patient to attend to contralesional space. It is hypothesised to be a result of damage to a network involving the frontal, parietal and cingulated cortices, basal ganglia and thalamus.
MATERIAL AND METHODS: The aim of this preliminary study was to verify this model of neglect in 22 right hemisphere-damaged acute stroke patients, using single photon emission-computed tomography (SPECT). The presence of a single rightsided vascular brain lesion was confirmed on CT and/or MRI. Hemispatial neglect, assessed with a battery of drawings, line bisection and line and shape cancellation tests, was observed in 12 cases.
RESULTS: Patients with neglect (compared with those without neglect) had more extensive hypoperfusion in the frontal and parietal cortex, as well as striatum and thalamus. Left-sided hypoperfusion in the parietal cortex and the thalamus was also significantly associated with neglect on SPECT imaging. Performance in three out of five psychological tasks commonly used to detect the presence of hemispatial neglect, such as drawing tests and line bisection test, was exclusively linked with damage to the parietal cortex of the right hemisphere, while the line cancellation test might be attributable to the lesion of the right striatum.
CONCLUSIONS: These findings support the model attributing hemispatial neglect to a unilateral defect in a cortico-striatothalamo-cortical loop. CBF SPECT imaging may provide a reliable description of the brain pathology associated with hemispatial neglect.

Abstract

BACKGROUND: Hemispatial neglect is characterised as a failure by a brain-damaged patient to attend to contralesional space. It is hypothesised to be a result of damage to a network involving the frontal, parietal and cingulated cortices, basal ganglia and thalamus.
MATERIAL AND METHODS: The aim of this preliminary study was to verify this model of neglect in 22 right hemisphere-damaged acute stroke patients, using single photon emission-computed tomography (SPECT). The presence of a single rightsided vascular brain lesion was confirmed on CT and/or MRI. Hemispatial neglect, assessed with a battery of drawings, line bisection and line and shape cancellation tests, was observed in 12 cases.
RESULTS: Patients with neglect (compared with those without neglect) had more extensive hypoperfusion in the frontal and parietal cortex, as well as striatum and thalamus. Left-sided hypoperfusion in the parietal cortex and the thalamus was also significantly associated with neglect on SPECT imaging. Performance in three out of five psychological tasks commonly used to detect the presence of hemispatial neglect, such as drawing tests and line bisection test, was exclusively linked with damage to the parietal cortex of the right hemisphere, while the line cancellation test might be attributable to the lesion of the right striatum.
CONCLUSIONS: These findings support the model attributing hemispatial neglect to a unilateral defect in a cortico-striatothalamo-cortical loop. CBF SPECT imaging may provide a reliable description of the brain pathology associated with hemispatial neglect.
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Keywords

hemispatial neglect; cerebral blood flow; single photon emission computed tomography; stroke

About this article
Title

Cerebral blood flow SPECT imaging in right hemisphere-damaged patients with hemispatial neglect. A pilot study

Journal

Nuclear Medicine Review

Issue

Vol 5, No 1 (2002)

Pages

49-51

Published online

2002-01-17

Bibliographic record

Nucl. Med. Rev 2002;5(1):49-51.

Keywords

hemispatial neglect
cerebral blood flow
single photon emission computed tomography
stroke

Authors

Krzysztof Jodzio
Piotr Lass
Walenty Nyka
Dariusz Gąsecki
Tomasz Bandurski
Justyna Scheffler

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