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Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: experimentally derived equations for a simplified determination
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Abstract
It is not always necessary to obtain values of the clearances by means of the laborious multi-sample procedure. In the paper there are presented formulas, based on experimental data, that form the basis of a simplified method for determination of ClPl and ClHp using single administration of 99mTc-HEPIDA. To arrive at the value of ClPl it is sufficient to withdraw 1 blood sample in the time range of 60 to 83 min post administration of the radio-pharmaceutical. If ClHp is required, additional collection of urine over the time from 0 to 88–100 min post injection is necessary.
The values of ClPl and ClHp obtained by the simplified procedure are in full accordance with those obtained by the reference method utilising a series of blood samples, collected from 5 to 90 min post injection. The simplified method is sufficient as a procedure for screening of patients for liver parenchymal damage.
Abstract
It is not always necessary to obtain values of the clearances by means of the laborious multi-sample procedure. In the paper there are presented formulas, based on experimental data, that form the basis of a simplified method for determination of ClPl and ClHp using single administration of 99mTc-HEPIDA. To arrive at the value of ClPl it is sufficient to withdraw 1 blood sample in the time range of 60 to 83 min post administration of the radio-pharmaceutical. If ClHp is required, additional collection of urine over the time from 0 to 88–100 min post injection is necessary.
The values of ClPl and ClHp obtained by the simplified procedure are in full accordance with those obtained by the reference method utilising a series of blood samples, collected from 5 to 90 min post injection. The simplified method is sufficient as a procedure for screening of patients for liver parenchymal damage.
Keywords
99mTc-HEPIDA: total plasma clearance; 99mTc-HEPIDA: hepatic and urinary clearance
Title
Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: experimentally derived equations for a simplified determination
Journal
Issue
Pages
43-48
Published online
2002-01-17
Page views
857
Article views/downloads
877
Bibliographic record
Nucl. Med. Rev 2002;5(1):43-48.
Keywords
99mTc-HEPIDA: total plasma clearance
99mTc-HEPIDA: hepatic and urinary clearance
Authors
Marian J. Surma