open access

Vol 5, No 1 (2002)
Published online: 2002-01-17
Submitted: 2012-01-23
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Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: experimentally derived equations for a simplified determination

Marian J. Surma
Nucl. Med. Rev 2002;5(1):43-48.

open access

Vol 5, No 1 (2002)
Published online: 2002-01-17
Submitted: 2012-01-23

Abstract

Determination of the plasma (ClPl) and specific hepatic clearance (ClHp) of 99mTc-HEPIDA is gaining acceptance as one of the best tests for the assessment of liver parenchyma functional capacity. A standard method utilises numerous blood samples, collected after injection of the radiopharmaceutical, plus collection of the urine if specific hepatic clearance is required.
It is not always necessary to obtain values of the clearances by means of the laborious multi-sample procedure. In the paper there are presented formulas, based on experimental data, that form the basis of a simplified method for determination of ClPl and ClHp using single administration of 99mTc-HEPIDA. To arrive at the value of ClPl it is sufficient to withdraw 1 blood sample in the time range of 60 to 83 min post administration of the radio-pharmaceutical. If ClHp is required, additional collection of urine over the time from 0 to 88–100 min post injection is necessary.
The values of ClPl and ClHp obtained by the simplified procedure are in full accordance with those obtained by the reference method utilising a series of blood samples, collected from 5 to 90 min post injection. The simplified method is sufficient as a procedure for screening of patients for liver parenchymal damage.

Abstract

Determination of the plasma (ClPl) and specific hepatic clearance (ClHp) of 99mTc-HEPIDA is gaining acceptance as one of the best tests for the assessment of liver parenchyma functional capacity. A standard method utilises numerous blood samples, collected after injection of the radiopharmaceutical, plus collection of the urine if specific hepatic clearance is required.
It is not always necessary to obtain values of the clearances by means of the laborious multi-sample procedure. In the paper there are presented formulas, based on experimental data, that form the basis of a simplified method for determination of ClPl and ClHp using single administration of 99mTc-HEPIDA. To arrive at the value of ClPl it is sufficient to withdraw 1 blood sample in the time range of 60 to 83 min post administration of the radio-pharmaceutical. If ClHp is required, additional collection of urine over the time from 0 to 88–100 min post injection is necessary.
The values of ClPl and ClHp obtained by the simplified procedure are in full accordance with those obtained by the reference method utilising a series of blood samples, collected from 5 to 90 min post injection. The simplified method is sufficient as a procedure for screening of patients for liver parenchymal damage.
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Keywords

99mTc-HEPIDA: total plasma clearance; 99mTc-HEPIDA: hepatic and urinary clearance

About this article
Title

Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: experimentally derived equations for a simplified determination

Journal

Nuclear Medicine Review

Issue

Vol 5, No 1 (2002)

Pages

43-48

Published online

2002-01-17

Bibliographic record

Nucl. Med. Rev 2002;5(1):43-48.

Keywords

99mTc-HEPIDA: total plasma clearance
99mTc-HEPIDA: hepatic and urinary clearance

Authors

Marian J. Surma

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