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Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia
open access
Abstract
MATERIAL AND METHODS: We therefore examined 10 patients with isolated heterozygous familial hypercholesterolemia (FH) being enrolled in a dietary run-in phase of 6 weeks after dietary counselling and a further 6 weeks of prickly pear addition. Uptake of autologous 123I-radiolabeled LDL was determined at entry as well as after 6 weeks of daily prickly pear ingestion.
RESULTS: We found a significant (p < 0.0001) increase in LDL-uptake by the liver (24.5 ± 4.9 vs. 31.1 ± 5.2%) and an enhanced decay in circulating blood. Total (298.0 → 268.0 mg/dl; p < 0.0001) and LDL-cholesterol (210.5 → 176.4 mg/dl; p = 0.0001) were significantly affected, while HDL (p = 0.0629) and triglycerides were not.
CONCLUSIONS: These findings demonstrate a significant upregulation of 123I-LDL binding by prickly pear in FH-patients invivo and indicate that prickly pear exerts a significant hypolipidemic action via receptor upregulation.
Abstract
MATERIAL AND METHODS: We therefore examined 10 patients with isolated heterozygous familial hypercholesterolemia (FH) being enrolled in a dietary run-in phase of 6 weeks after dietary counselling and a further 6 weeks of prickly pear addition. Uptake of autologous 123I-radiolabeled LDL was determined at entry as well as after 6 weeks of daily prickly pear ingestion.
RESULTS: We found a significant (p < 0.0001) increase in LDL-uptake by the liver (24.5 ± 4.9 vs. 31.1 ± 5.2%) and an enhanced decay in circulating blood. Total (298.0 → 268.0 mg/dl; p < 0.0001) and LDL-cholesterol (210.5 → 176.4 mg/dl; p = 0.0001) were significantly affected, while HDL (p = 0.0629) and triglycerides were not.
CONCLUSIONS: These findings demonstrate a significant upregulation of 123I-LDL binding by prickly pear in FH-patients invivo and indicate that prickly pear exerts a significant hypolipidemic action via receptor upregulation.
Keywords
prickly pear; LDL-receptor; familial hypercholesterolemia; 123I-LDL-labeling
Title
Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia
Journal
Issue
Pages
35-39
Published online
2003-01-03
Page views
1433
Article views/downloads
2112
Bibliographic record
Nucl. Med. Rev 2003;6(1):35-39.
Keywords
prickly pear
LDL-receptor
familial hypercholesterolemia
123I-LDL-labeling
Authors
Barbara Palumbo
Yannis Efthimiou
Jorgos Stamatopoulos
Anthony Oguogho
Alexandra Budinsky
Renato Palumbo
Helmut Sinzinger