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99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance
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Abstract
The liver damage has been evaluated on the basis of 5 biochemical tests (AspAT, ALAT, GGTP, bilirubine serum concentration, proteinogram) and a score system used for total impairment, which was calculated for each patient.
Normal range of ClPl and ClHp was determined from a study on healthy individuals (volunteers). The results seem independent of age, but show sex differences. The following values (mean ± SD) of ClHp were found in males and females of: (181 ± 31) ml//min/1.73 m2 and (158 ± 22) ml/min/1.73m2, and of ClPl were (224 ± 33) ml/min/1.73 m2 and (202 ± 25) ml/min/1.73 m2 respectively. Accepted lower boundaries of both quantities (mean –2SD) are 115 ml/min/1.73 m2 and 150 ml/min/1.73 m2 correspondingly.
Negative correlation of individual values of both clearances in all patients with individual score of liver damage were highly significant and correlation coefficients obtained were higher for ClHp (r = –0.63) than those for ClPl (r= –0.56). Factorial analysis was performed with the intention of seeing which of the studied factors had the highest factor loading for parenchyma performance that was assumed as the common factor responsible for correlations. The highest value was obtained for hepatic clearance (ClHp) of 99mTc-HEPIDA. In conclusion this quantity seems highly promising as a clinically useful test for assessment of liver performance, both in screening for liver damage and for monitoring of organ conditions during therapy and follow-up of patients.
Abstract
The liver damage has been evaluated on the basis of 5 biochemical tests (AspAT, ALAT, GGTP, bilirubine serum concentration, proteinogram) and a score system used for total impairment, which was calculated for each patient.
Normal range of ClPl and ClHp was determined from a study on healthy individuals (volunteers). The results seem independent of age, but show sex differences. The following values (mean ± SD) of ClHp were found in males and females of: (181 ± 31) ml//min/1.73 m2 and (158 ± 22) ml/min/1.73m2, and of ClPl were (224 ± 33) ml/min/1.73 m2 and (202 ± 25) ml/min/1.73 m2 respectively. Accepted lower boundaries of both quantities (mean –2SD) are 115 ml/min/1.73 m2 and 150 ml/min/1.73 m2 correspondingly.
Negative correlation of individual values of both clearances in all patients with individual score of liver damage were highly significant and correlation coefficients obtained were higher for ClHp (r = –0.63) than those for ClPl (r= –0.56). Factorial analysis was performed with the intention of seeing which of the studied factors had the highest factor loading for parenchyma performance that was assumed as the common factor responsible for correlations. The highest value was obtained for hepatic clearance (ClHp) of 99mTc-HEPIDA. In conclusion this quantity seems highly promising as a clinically useful test for assessment of liver performance, both in screening for liver damage and for monitoring of organ conditions during therapy and follow-up of patients.
Keywords
99mTc-HEPIDA total plasma clearance; 99mTc-HEPIDA hepatic clearance
Title
99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance
Journal
Issue
Pages
23-28
Published online
2003-01-03
Page views
969
Article views/downloads
1077
Bibliographic record
Nucl. Med. Rev 2003;6(1):23-28.
Keywords
99mTc-HEPIDA total plasma clearance
99mTc-HEPIDA hepatic clearance
Authors
Izabela Frieske
Marian J. Surma
Małgorzata Bieńkiewicz
Jolanta Białkowska-Warzecha
Julian Liniecki
Jan Kuydowicz
Jacek Kuśmierek