open access

Vol 6, No 1 (2003)
Published online: 2003-01-03
Submitted: 2012-01-23
Get Citation

99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance

Izabela Frieske, Marian J. Surma, Małgorzata Bieńkiewicz, Jolanta Białkowska-Warzecha, Julian Liniecki, Jan Kuydowicz, Jacek Kuśmierek
Nucl. Med. Rev 2003;6(1):23-28.

open access

Vol 6, No 1 (2003)
Published online: 2003-01-03
Submitted: 2012-01-23

Abstract

Plasma clearance of 99mTc-HEPIDA (ClPl) has been used for two decades for assessment of liver function in patients with diseases of this organ. A specific determination of 99mTc-HEPIDA liver clearance (ClHp) has been developed that provides more direct possibility to evaluate performance of liver parenchyma. Both tests have been studied in healthy volunteers of varying age (48 individuals) and in 83 patients with varying degree of liver damage.
The liver damage has been evaluated on the basis of 5 biochemical tests (AspAT, ALAT, GGTP, bilirubine serum concentration, proteinogram) and a score system used for total impairment, which was calculated for each patient.
Normal range of ClPl and ClHp was determined from a study on healthy individuals (volunteers). The results seem independent of age, but show sex differences. The following values (mean ± SD) of ClHp were found in males and females of: (181 ± 31) ml//min/1.73 m2 and (158 ± 22) ml/min/1.73m2, and of ClPl were (224 ± 33) ml/min/1.73 m2 and (202 ± 25) ml/min/1.73 m2 respectively. Accepted lower boundaries of both quantities (mean –2SD) are 115 ml/min/1.73 m2 and 150 ml/min/1.73 m2 correspondingly.
Negative correlation of individual values of both clearances in all patients with individual score of liver damage were highly significant and correlation coefficients obtained were higher for ClHp (r = –0.63) than those for ClPl (r= –0.56). Factorial analysis was performed with the intention of seeing which of the studied factors had the highest factor loading for parenchyma performance that was assumed as the common factor responsible for correlations. The highest value was obtained for hepatic clearance (ClHp) of 99mTc-HEPIDA. In conclusion this quantity seems highly promising as a clinically useful test for assessment of liver performance, both in screening for liver damage and for monitoring of organ conditions during therapy and follow-up of patients.

Abstract

Plasma clearance of 99mTc-HEPIDA (ClPl) has been used for two decades for assessment of liver function in patients with diseases of this organ. A specific determination of 99mTc-HEPIDA liver clearance (ClHp) has been developed that provides more direct possibility to evaluate performance of liver parenchyma. Both tests have been studied in healthy volunteers of varying age (48 individuals) and in 83 patients with varying degree of liver damage.
The liver damage has been evaluated on the basis of 5 biochemical tests (AspAT, ALAT, GGTP, bilirubine serum concentration, proteinogram) and a score system used for total impairment, which was calculated for each patient.
Normal range of ClPl and ClHp was determined from a study on healthy individuals (volunteers). The results seem independent of age, but show sex differences. The following values (mean ± SD) of ClHp were found in males and females of: (181 ± 31) ml//min/1.73 m2 and (158 ± 22) ml/min/1.73m2, and of ClPl were (224 ± 33) ml/min/1.73 m2 and (202 ± 25) ml/min/1.73 m2 respectively. Accepted lower boundaries of both quantities (mean –2SD) are 115 ml/min/1.73 m2 and 150 ml/min/1.73 m2 correspondingly.
Negative correlation of individual values of both clearances in all patients with individual score of liver damage were highly significant and correlation coefficients obtained were higher for ClHp (r = –0.63) than those for ClPl (r= –0.56). Factorial analysis was performed with the intention of seeing which of the studied factors had the highest factor loading for parenchyma performance that was assumed as the common factor responsible for correlations. The highest value was obtained for hepatic clearance (ClHp) of 99mTc-HEPIDA. In conclusion this quantity seems highly promising as a clinically useful test for assessment of liver performance, both in screening for liver damage and for monitoring of organ conditions during therapy and follow-up of patients.
Get Citation

Keywords

99mTc-HEPIDA total plasma clearance; 99mTc-HEPIDA hepatic clearance

About this article
Title

99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance

Journal

Nuclear Medicine Review

Issue

Vol 6, No 1 (2003)

Pages

23-28

Published online

2003-01-03

Bibliographic record

Nucl. Med. Rev 2003;6(1):23-28.

Keywords

99mTc-HEPIDA total plasma clearance
99mTc-HEPIDA hepatic clearance

Authors

Izabela Frieske
Marian J. Surma
Małgorzata Bieńkiewicz
Jolanta Białkowska-Warzecha
Julian Liniecki
Jan Kuydowicz
Jacek Kuśmierek

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl