Vol 6, No 1 (2003)
Published online: 2003-01-03
Preparation of Holmium-166 Labelled Macroaggregates for radionuclide synovectomy
Nucl. Med. Rev 2003;6(1):1-4.
Abstract
BACKGROUND: Radionuclide synovectomy (radiation synovectomy)
is an alternative method that cures patients with rheumatoid
arthritis diseases without surgery. During treatment, the
suspension of the 166Ho-macroaggregates radioactive particles
(166Ho-MA) is administrated via intra-articular injection into the
target joint to destroy the inflamed synovium.
MATERIAL AND METHODS: The isotope of 166Ho (Eβ max = 1.84 MeV, T½ = 26.8 hr) was prepared by the 165Ho(n, γ)166Ho reaction in the LWR-15 nuclear reactor (8–10 MW) using approximate neutron flux 1014 cm-2s-1.
RESULTS: The particles of Ho-Macroaggregates with suitable dimension 1–20 μm and the mean diameter of 8.5 μm were prepared. High in-vitro stability was obtained after incubation of neutron-irradiated Ho-Macroaggregates in saline solution (0.9% NaCl). The in-vivo stability on rats was verified as well.
CONCLUSIONS: High in-vivo and in-vitro stability as well as supporting gamma radiation of Ho-166 make the Macroaggregates a prospective agent for radionuclide synovectomy. The method of preparation is relatively easy and allows for the production of particles of a suitable dimension with a sufficient amount of radioactivity of Ho-166 for the treatment of the rheumatoid arthritis.
MATERIAL AND METHODS: The isotope of 166Ho (Eβ max = 1.84 MeV, T½ = 26.8 hr) was prepared by the 165Ho(n, γ)166Ho reaction in the LWR-15 nuclear reactor (8–10 MW) using approximate neutron flux 1014 cm-2s-1.
RESULTS: The particles of Ho-Macroaggregates with suitable dimension 1–20 μm and the mean diameter of 8.5 μm were prepared. High in-vitro stability was obtained after incubation of neutron-irradiated Ho-Macroaggregates in saline solution (0.9% NaCl). The in-vivo stability on rats was verified as well.
CONCLUSIONS: High in-vivo and in-vitro stability as well as supporting gamma radiation of Ho-166 make the Macroaggregates a prospective agent for radionuclide synovectomy. The method of preparation is relatively easy and allows for the production of particles of a suitable dimension with a sufficient amount of radioactivity of Ho-166 for the treatment of the rheumatoid arthritis.
Keywords: radionuclide synovectomyradiation synovectomyHo-166
