Vol 6, No 1 (2003)
Published online: 2003-01-03
Submitted: 2012-01-23
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Preparation of Holmium-166 Labelled Macroaggregates for radionuclide synovectomy

Martin Kropáček, František Melichar, Kateřina Henková, Marie Konopková
Nucl. Med. Rev 2003;6(1):1-4.
Vol 6, No 1 (2003)
Published online: 2003-01-03
Submitted: 2012-01-23

Abstract

BACKGROUND: Radionuclide synovectomy (radiation synovectomy) is an alternative method that cures patients with rheumatoid arthritis diseases without surgery. During treatment, the suspension of the 166Ho-macroaggregates radioactive particles (166Ho-MA) is administrated via intra-articular injection into the target joint to destroy the inflamed synovium.
MATERIAL AND METHODS: The isotope of 166Ho (Eβ max = 1.84 MeV, T½ = 26.8 hr) was prepared by the 165Ho(n, γ)166Ho reaction in the LWR-15 nuclear reactor (8–10 MW) using approximate neutron flux 1014 cm-2s-1.
RESULTS: The particles of Ho-Macroaggregates with suitable dimension 1–20 μm and the mean diameter of 8.5 μm were prepared. High in-vitro stability was obtained after incubation of neutron-irradiated Ho-Macroaggregates in saline solution (0.9% NaCl). The in-vivo stability on rats was verified as well.
CONCLUSIONS: High in-vivo and in-vitro stability as well as supporting gamma radiation of Ho-166 make the Macroaggregates a prospective agent for radionuclide synovectomy. The method of preparation is relatively easy and allows for the production of particles of a suitable dimension with a sufficient amount of radioactivity of Ho-166 for the treatment of the rheumatoid arthritis.

Abstract

BACKGROUND: Radionuclide synovectomy (radiation synovectomy) is an alternative method that cures patients with rheumatoid arthritis diseases without surgery. During treatment, the suspension of the 166Ho-macroaggregates radioactive particles (166Ho-MA) is administrated via intra-articular injection into the target joint to destroy the inflamed synovium.
MATERIAL AND METHODS: The isotope of 166Ho (Eβ max = 1.84 MeV, T½ = 26.8 hr) was prepared by the 165Ho(n, γ)166Ho reaction in the LWR-15 nuclear reactor (8–10 MW) using approximate neutron flux 1014 cm-2s-1.
RESULTS: The particles of Ho-Macroaggregates with suitable dimension 1–20 μm and the mean diameter of 8.5 μm were prepared. High in-vitro stability was obtained after incubation of neutron-irradiated Ho-Macroaggregates in saline solution (0.9% NaCl). The in-vivo stability on rats was verified as well.
CONCLUSIONS: High in-vivo and in-vitro stability as well as supporting gamma radiation of Ho-166 make the Macroaggregates a prospective agent for radionuclide synovectomy. The method of preparation is relatively easy and allows for the production of particles of a suitable dimension with a sufficient amount of radioactivity of Ho-166 for the treatment of the rheumatoid arthritis.
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Keywords

radionuclide synovectomy; radiation synovectomy; Ho-166

About this article
Title

Preparation of Holmium-166 Labelled Macroaggregates for radionuclide synovectomy

Journal

Nuclear Medicine Review

Issue

Vol 6, No 1 (2003)

Pages

1-4

Published online

2003-01-03

Bibliographic record

Nucl. Med. Rev 2003;6(1):1-4.

Keywords

radionuclide synovectomy
radiation synovectomy
Ho-166

Authors

Martin Kropáček
František Melichar
Kateřina Henková
Marie Konopková

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