open access

Vol 7, No 1 (2004)
Reviews
Published online: 2004-01-22
Submitted: 2012-01-23
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Apoptosis: its pathophysiology and monitoring. The role of apoptosis in the radioiodine therapy of hyperthyroidism

Antoni J. Sopotyk, Franciszek Rogowski, Adam Parfieńczyk
Nucl. Med. Rev 2004;7(1):53-58.

open access

Vol 7, No 1 (2004)
Reviews
Published online: 2004-01-22
Submitted: 2012-01-23

Abstract

The review aims to give an up to date understanding of the mechanisms of apoptosis (programmed cell death), the methods of detecting apoptosis, in particular with regard to imaging such changes non-invasively. Radioiodine (I-131) is a gamma and beta emitting radionuclide and is commonplace in the treatment of hyperthyroidism. I-131 therapy relies on the destruction of thyroid tissue by beta radiation, and such destruction is proposed to be partly as a result of apoptosis. The review undertakes to explore and provoke research into the mechanisms of thyroid cell destruction by I-131, and whether such changes are able to be detected or monitored. Current knowledge concerning apoptosis in the thyroid gland in diseased states (including cancer) are described. The clinical significance of monitoring and modifying apoptosis are emphasized. Furthermore, overt and late destruction of thyroid tissue following I-131 therapy requires elaboration, and the relevance of detecting and modifying thyroid cell apoptosis following I-131 are questioned.

Abstract

The review aims to give an up to date understanding of the mechanisms of apoptosis (programmed cell death), the methods of detecting apoptosis, in particular with regard to imaging such changes non-invasively. Radioiodine (I-131) is a gamma and beta emitting radionuclide and is commonplace in the treatment of hyperthyroidism. I-131 therapy relies on the destruction of thyroid tissue by beta radiation, and such destruction is proposed to be partly as a result of apoptosis. The review undertakes to explore and provoke research into the mechanisms of thyroid cell destruction by I-131, and whether such changes are able to be detected or monitored. Current knowledge concerning apoptosis in the thyroid gland in diseased states (including cancer) are described. The clinical significance of monitoring and modifying apoptosis are emphasized. Furthermore, overt and late destruction of thyroid tissue following I-131 therapy requires elaboration, and the relevance of detecting and modifying thyroid cell apoptosis following I-131 are questioned.
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Keywords

apoptosis; thyroid; radioiodine (I-131)

About this article
Title

Apoptosis: its pathophysiology and monitoring. The role of apoptosis in the radioiodine therapy of hyperthyroidism

Journal

Nuclear Medicine Review

Issue

Vol 7, No 1 (2004)

Pages

53-58

Published online

2004-01-22

Bibliographic record

Nucl. Med. Rev 2004;7(1):53-58.

Keywords

apoptosis
thyroid
radioiodine (I-131)

Authors

Antoni J. Sopotyk
Franciszek Rogowski
Adam Parfieńczyk

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