Vol 7, No 1 (2004)
Review paper
Submitted: 2012-01-23
Published online: 2004-01-22
Apoptosis: its pathophysiology and monitoring. The role of apoptosis in the radioiodine therapy of hyperthyroidism
Antoni J. Sopotyk, Franciszek Rogowski, Adam Parfieńczyk
Nucl. Med. Rev 2004;7(1):53-58.
Vol 7, No 1 (2004)
Reviews
Submitted: 2012-01-23
Published online: 2004-01-22
Abstract
The review aims to give an up to date understanding of the
mechanisms of apoptosis (programmed cell death), the methods
of detecting apoptosis, in particular with regard to imaging
such changes non-invasively. Radioiodine (I-131) is a gamma
and beta emitting radionuclide and is commonplace in the treatment
of hyperthyroidism. I-131 therapy relies on the destruction
of thyroid tissue by beta radiation, and such destruction is
proposed to be partly as a result of apoptosis. The review undertakes
to explore and provoke research into the mechanisms
of thyroid cell destruction by I-131, and whether such changes
are able to be detected or monitored. Current knowledge concerning
apoptosis in the thyroid gland in diseased states (including
cancer) are described. The clinical significance of monitoring
and modifying apoptosis are emphasized. Furthermore,
overt and late destruction of thyroid tissue following I-131 therapy
requires elaboration, and the relevance of detecting and
modifying thyroid cell apoptosis following I-131 are questioned.
Abstract
The review aims to give an up to date understanding of the
mechanisms of apoptosis (programmed cell death), the methods
of detecting apoptosis, in particular with regard to imaging
such changes non-invasively. Radioiodine (I-131) is a gamma
and beta emitting radionuclide and is commonplace in the treatment
of hyperthyroidism. I-131 therapy relies on the destruction
of thyroid tissue by beta radiation, and such destruction is
proposed to be partly as a result of apoptosis. The review undertakes
to explore and provoke research into the mechanisms
of thyroid cell destruction by I-131, and whether such changes
are able to be detected or monitored. Current knowledge concerning
apoptosis in the thyroid gland in diseased states (including
cancer) are described. The clinical significance of monitoring
and modifying apoptosis are emphasized. Furthermore,
overt and late destruction of thyroid tissue following I-131 therapy
requires elaboration, and the relevance of detecting and
modifying thyroid cell apoptosis following I-131 are questioned.
Keywords
apoptosis; thyroid; radioiodine (I-131)
Title
Apoptosis: its pathophysiology and monitoring. The role of apoptosis in the radioiodine therapy of hyperthyroidism
Journal
Nuclear Medicine Review
Issue
Vol 7, No 1 (2004)
Article type
Review paper
Pages
53-58
Published online
2004-01-22
Page views
588
Article views/downloads
1183
Bibliographic record
Nucl. Med. Rev 2004;7(1):53-58.
Keywords
apoptosis
thyroid
radioiodine (I-131)
Authors
Antoni J. Sopotyk
Franciszek Rogowski
Adam Parfieńczyk