open access

Vol 7, No 1 (2004)
Published online: 2004-01-22
Submitted: 2012-01-23
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Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function

Vladimir Obradović, Vera Artiko, Bozina Radević, Branka Dapcević, Nebojsa Petrović
Nucl. Med. Rev 2004;7(1):21-25.

open access

Vol 7, No 1 (2004)
Published online: 2004-01-22
Submitted: 2012-01-23

Abstract

BACKGROUND: The aim of the study was the evaluation of the perfusion, morphology and biliary three patency of liver transplants employing two radionuclide methods.
MATERIAL AND METHODS: The study was performed on 10 controls and 10 patients after an orthotopic transplantation (up to two years). "First pass" dynamic acquisition was performed with a scintillation camera, after a bolus injection of 360 MBq 99mTc-diethyl- IDA, (60 frames/60s), continued by a 59 minute (1 frame/min) slower dynamic study. From the liver and kidney activity during the "first pass" study, the hepatic perfusion index (HPI) was calculated using slope-analysis. Hepatobiliary scintigrams obtained during second phase of the study were analyzed for morphology, and parenchymal and hepatobiliary TA curves were generated and analyzed according to the time to maximal activity (Tmax) and the time to half of maximum activity (T/2).
RESULTS: In comparison to the controls (HPI, X = 0.64.5 ± 0.05%) portal perfusion had slightly (X = 0.68 ± 0.04%), but not significantly (p > 0.05) increased. In 3 patients, the biliary phase of hepatobiliary scintigraphy showed an increased accumulation of the radiopharmaceutical in the left (n = 1) or right (n = 2) hepatic duct. The uptake of the radiopharmaceutical (Tmax, X = 18.5 ± 2.9 min) was slightly, but not significantly (p > 0.05) delayed in comparison to the controls (X = 14.2 ± 3.4 min), while excretion was significantly (p < 0.05) prolonged (X = 59.5 ± 12.1 min) (X = 34.2 ± 4.1 min). Intrahepatic bile flow was insignificantly (p > 0.05) prolonged (X = 31.3 ± 3.7 min) in comparison to the controls (X = 25.7 ± 3.5 min) while extrahepatic bile flow was high, significantly (p < 0.01) prolonged (X = 89.0 ± 14.3 min) than physiological one (X = 45.0 ± 7.2 min).
CONCLUSIONS: Radionuclide methods are noninvasive, sensitive and valuable in monitoring liver transplants.

Abstract

BACKGROUND: The aim of the study was the evaluation of the perfusion, morphology and biliary three patency of liver transplants employing two radionuclide methods.
MATERIAL AND METHODS: The study was performed on 10 controls and 10 patients after an orthotopic transplantation (up to two years). "First pass" dynamic acquisition was performed with a scintillation camera, after a bolus injection of 360 MBq 99mTc-diethyl- IDA, (60 frames/60s), continued by a 59 minute (1 frame/min) slower dynamic study. From the liver and kidney activity during the "first pass" study, the hepatic perfusion index (HPI) was calculated using slope-analysis. Hepatobiliary scintigrams obtained during second phase of the study were analyzed for morphology, and parenchymal and hepatobiliary TA curves were generated and analyzed according to the time to maximal activity (Tmax) and the time to half of maximum activity (T/2).
RESULTS: In comparison to the controls (HPI, X = 0.64.5 ± 0.05%) portal perfusion had slightly (X = 0.68 ± 0.04%), but not significantly (p > 0.05) increased. In 3 patients, the biliary phase of hepatobiliary scintigraphy showed an increased accumulation of the radiopharmaceutical in the left (n = 1) or right (n = 2) hepatic duct. The uptake of the radiopharmaceutical (Tmax, X = 18.5 ± 2.9 min) was slightly, but not significantly (p > 0.05) delayed in comparison to the controls (X = 14.2 ± 3.4 min), while excretion was significantly (p < 0.05) prolonged (X = 59.5 ± 12.1 min) (X = 34.2 ± 4.1 min). Intrahepatic bile flow was insignificantly (p > 0.05) prolonged (X = 31.3 ± 3.7 min) in comparison to the controls (X = 25.7 ± 3.5 min) while extrahepatic bile flow was high, significantly (p < 0.01) prolonged (X = 89.0 ± 14.3 min) than physiological one (X = 45.0 ± 7.2 min).
CONCLUSIONS: Radionuclide methods are noninvasive, sensitive and valuable in monitoring liver transplants.
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Keywords

radionuclide angiography; hepatobiliary scintigraphy; nuclear medicine techniques; liver transplant

About this article
Title

Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function

Journal

Nuclear Medicine Review

Issue

Vol 7, No 1 (2004)

Pages

21-25

Published online

2004-01-22

Bibliographic record

Nucl. Med. Rev 2004;7(1):21-25.

Keywords

radionuclide angiography
hepatobiliary scintigraphy
nuclear medicine techniques
liver transplant

Authors

Vladimir Obradović
Vera Artiko
Bozina Radević
Branka Dapcević
Nebojsa Petrović

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