open access

Vol 8, No 1 (2005)
Original articles
Published online: 2005-06-21
Submitted: 2012-01-23
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Reassessment of the reproducibility of Technetium-99m mercaptoacetyltriglycine clearance

Carlos De Sadeleer
Nucl. Med. Rev 2005;8(1):15-20.

open access

Vol 8, No 1 (2005)
Original articles
Published online: 2005-06-21
Submitted: 2012-01-23

Abstract

BACKGROUND: Conflicting results have been published concerning the reproducibility of Tc-99m MAG3 clearance. The aim of the study was to reevaluate again this reproducibility on a large prospective series of healthy volunteers.
MATERIAL AND METHODS: Fifty subjects underwent three successive tests performed at 1-week interval. The physiological conditions were controlled as much as possible and all experimental measurements were rigorously double-checked. Renal clearances were calculated using single sample algorithms.
RESULTS: Thin layer chromatography demonstrated a radiochemical purity of more than 92% (mean 93.8%; SD 1.6%; range 92.0–96.4%). The mean (and SD) of 44th minute plasma concentrations for the three successive measurements were respectively 1.8 ± 0.4, 2.1 ± 0.4 and 1.9 ± 0.4 (%dose/liter). The mean changes (and S.D. of differences) between two tests were 0.26 ± 0.29, –0.08 ± 0.5 and 0.18 ± 0.30 respectively between tests 1 and 2, tests 1 and 3, and tests 2 and 3. Using Bubeck’s algorithm, the mean clearance values (ml/min/1.73 m2) were 268.8 (range 201.4–336.8), 247.2 (range 170.5–290.3), and 262.8 (range 187.4–340.0) respectively for the first, second and third measurements. Using Russell’s approach, the mean clearance values were respectively 314.9 (range: 208.7–441.7), 280.1 (range: 167.5–358.6), and 305.4 (range: 189.5–447.9).
CONCLUSIONS: High differences were observed between the 3 tests. Using Russell´s formula, the SD of differences between two tests was respectively 35.8, 47.7 and 57.7 ml/min/1.73 m2 between tests 1 and 2, tests 1 and 3, and tests 2 and 3. Whether such a large variability is acceptable in clinical practice depends solely on what the clinician is expecting.

Abstract

BACKGROUND: Conflicting results have been published concerning the reproducibility of Tc-99m MAG3 clearance. The aim of the study was to reevaluate again this reproducibility on a large prospective series of healthy volunteers.
MATERIAL AND METHODS: Fifty subjects underwent three successive tests performed at 1-week interval. The physiological conditions were controlled as much as possible and all experimental measurements were rigorously double-checked. Renal clearances were calculated using single sample algorithms.
RESULTS: Thin layer chromatography demonstrated a radiochemical purity of more than 92% (mean 93.8%; SD 1.6%; range 92.0–96.4%). The mean (and SD) of 44th minute plasma concentrations for the three successive measurements were respectively 1.8 ± 0.4, 2.1 ± 0.4 and 1.9 ± 0.4 (%dose/liter). The mean changes (and S.D. of differences) between two tests were 0.26 ± 0.29, –0.08 ± 0.5 and 0.18 ± 0.30 respectively between tests 1 and 2, tests 1 and 3, and tests 2 and 3. Using Bubeck’s algorithm, the mean clearance values (ml/min/1.73 m2) were 268.8 (range 201.4–336.8), 247.2 (range 170.5–290.3), and 262.8 (range 187.4–340.0) respectively for the first, second and third measurements. Using Russell’s approach, the mean clearance values were respectively 314.9 (range: 208.7–441.7), 280.1 (range: 167.5–358.6), and 305.4 (range: 189.5–447.9).
CONCLUSIONS: High differences were observed between the 3 tests. Using Russell´s formula, the SD of differences between two tests was respectively 35.8, 47.7 and 57.7 ml/min/1.73 m2 between tests 1 and 2, tests 1 and 3, and tests 2 and 3. Whether such a large variability is acceptable in clinical practice depends solely on what the clinician is expecting.
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Keywords

Tc-99m MAG3; clearance; precision; reproducibility; Russell; Bubeck

About this article
Title

Reassessment of the reproducibility of Technetium-99m mercaptoacetyltriglycine clearance

Journal

Nuclear Medicine Review

Issue

Vol 8, No 1 (2005)

Pages

15-20

Published online

2005-06-21

Bibliographic record

Nucl. Med. Rev 2005;8(1):15-20.

Keywords

Tc-99m MAG3
clearance
precision
reproducibility
Russell
Bubeck

Authors

Carlos De Sadeleer

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