open access
Optimisation of statistical methodologies for a better diagnosis of neurological and psychiatric disorders by means of SPECT
open access
Abstract
An early diagnosis of neuro-psychiatric diseases and the assessment of "natural" changes of regional cerebral blood flow (rCBF) distribution during normal aging are hence of utmost importance.
In the recent past brain disorders have extensively been investigated by means of optimised nuclear medicine techniques, instruments and algorithms. Diagnosis can be better achieved by identifying those structures in which CBF or metabolism deviate from normality resulting in significant changes as compared to a reference database.
In the present paper we present some studies investigating, by means of recently implemented diagnostic tools, patients bearer of various neuro-psychiatric disorders. The improved nuclear medicine techniques and instrumentation, the state-of-the-art software for brain imaging standardisation and the use of sophisticated multivariate data analysis are extensively reviewed.
Abstract
An early diagnosis of neuro-psychiatric diseases and the assessment of "natural" changes of regional cerebral blood flow (rCBF) distribution during normal aging are hence of utmost importance.
In the recent past brain disorders have extensively been investigated by means of optimised nuclear medicine techniques, instruments and algorithms. Diagnosis can be better achieved by identifying those structures in which CBF or metabolism deviate from normality resulting in significant changes as compared to a reference database.
In the present paper we present some studies investigating, by means of recently implemented diagnostic tools, patients bearer of various neuro-psychiatric disorders. The improved nuclear medicine techniques and instrumentation, the state-of-the-art software for brain imaging standardisation and the use of sophisticated multivariate data analysis are extensively reviewed.
Keywords
SPECT; neuro-psychiatric diseases; standardisation software; multivariate analysis; functional connectivity
Title
Optimisation of statistical methodologies for a better diagnosis of neurological and psychiatric disorders by means of SPECT
Journal
Issue
Article type
Review paper
Pages
140-149
Published online
2005-06-23
Page views
543
Article views/downloads
1723
Bibliographic record
Nucl. Med. Rev 2005;8(2):140-149.
Keywords
SPECT
neuro-psychiatric diseases
standardisation software
multivariate analysis
functional connectivity
Authors
Marco Pagani
Dario Salmaso
Katalin Borbely