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Combination of physical exercise and adenosine improves accuracy of automatic calculation of stress LVEF in gated SPECT using QGS software
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Abstract
MATERIAL AND METHODS: One hundred patients who had stress Gated SPECT were retrospectively included in this study. Gated data of those who had adenosine only (50 patients = group A) was compared with those obtained in another group of 50 patients who had added bicycle exercise (Group B). All had identical image acquisition protocol using 99mTc-tetrofosmine. Clinical adverse effects, changes in blood pressure (BP), heart rate (HR), and ECG were monitored. Visual assessment of subdiaphragmatic uptake and accuracy of automatic regions of interest (ROI's) drawn by the software were noted. Regions of interest that involved sub-diaphragmatic uptake and resulting in low LVEF were manually adjusted to include the left ventricle only, and the frequency of manual adjustment was noted.
RESULTS: No significant difference was noted in age, sex, baseline BP and HR between groups A and B. Adverse effects occurred less often in group B compared to group A (12% vs. 24%, p = 0.118). Maximum HR and BP achieved during stress were significantly higher in group B compared to group A (p = 0.025, p = 0.001 respectively). The number of patients who had faulty ROI's and low LVEF, who needed manual adjustment of ROI's, were higher in group A compared to group B (16% vs. 6%, p = 0.025). The values of LVEF showed significant improvement following manual adjustment of ROI's, increasing from a mean of 19.63 ± 15.96 to 62.13 ± 7.55 (p = 0.0001) and from 17.33 ± 9.5 to 49.67 ± 7.7 (p = 0.0014) in groups A and B respectively.
CONCLUSION: The addition of exercise to adenosine significantly improves the automatic calculation of LVEF by QGS software during Gated SPECT and reduces the need for manual adjustment.
Abstract
MATERIAL AND METHODS: One hundred patients who had stress Gated SPECT were retrospectively included in this study. Gated data of those who had adenosine only (50 patients = group A) was compared with those obtained in another group of 50 patients who had added bicycle exercise (Group B). All had identical image acquisition protocol using 99mTc-tetrofosmine. Clinical adverse effects, changes in blood pressure (BP), heart rate (HR), and ECG were monitored. Visual assessment of subdiaphragmatic uptake and accuracy of automatic regions of interest (ROI's) drawn by the software were noted. Regions of interest that involved sub-diaphragmatic uptake and resulting in low LVEF were manually adjusted to include the left ventricle only, and the frequency of manual adjustment was noted.
RESULTS: No significant difference was noted in age, sex, baseline BP and HR between groups A and B. Adverse effects occurred less often in group B compared to group A (12% vs. 24%, p = 0.118). Maximum HR and BP achieved during stress were significantly higher in group B compared to group A (p = 0.025, p = 0.001 respectively). The number of patients who had faulty ROI's and low LVEF, who needed manual adjustment of ROI's, were higher in group A compared to group B (16% vs. 6%, p = 0.025). The values of LVEF showed significant improvement following manual adjustment of ROI's, increasing from a mean of 19.63 ± 15.96 to 62.13 ± 7.55 (p = 0.0001) and from 17.33 ± 9.5 to 49.67 ± 7.7 (p = 0.0014) in groups A and B respectively.
CONCLUSION: The addition of exercise to adenosine significantly improves the automatic calculation of LVEF by QGS software during Gated SPECT and reduces the need for manual adjustment.
Keywords
gated SPECT; adenosine; physical exercise; sub-diaphragmatic uptake; LVEF
Title
Combination of physical exercise and adenosine improves accuracy of automatic calculation of stress LVEF in gated SPECT using QGS software
Journal
Issue
Pages
90-92
Published online
2005-06-23
Page views
497
Article views/downloads
1237
Bibliographic record
Nucl. Med. Rev 2005;8(2):90-92.
Keywords
gated SPECT
adenosine
physical exercise
sub-diaphragmatic uptake
LVEF
Authors
Neda Tehranipour
Adil AL-Nahhas
David J. Towey