Vol 9, No 1 (2006)
Published online: 2006-01-25
Specific 99mtc-hepida hepatic clearance - essential value ranges from a clinical stand-point
Nucl. Med. Rev 2006;9(1):56-59.
Abstract
BACKGROUND: Determinations of plasma 99mTc-HEPIDA clearance
(ClPl) have been performed in some centres for 30 years
to assess liver parenchyma damage, mostly for monitoring
of organ performance in the course of various diseases. The main
disadvantage of such a procedure rests with the fact that elimination
of the compound from the system occurs not only via
the liver and gall ducts, but also via the urinary route; the contribution
of the latter compound being quite variable. This circumstance
may lead to false assessment of liver parenchyma
performance. A method has been developed therefore for assessment
of specific hepatic clearance of 99mTc-HEPIDA (ClHp).
Using this method it was demonstrated that results of ClHp correlated
better with independently assessed degrees of liver
impairment than did the values of ClPl.
MATERIAL AND METHODS: To delineate ranges of ClHp that would provide valuable clinical information 134 individuals were studied, of whom 48 served as healthy controls and 86 had varying degrees of livers function impairment, resulting from various chronic diseases affecting the organs functional capacity. The latter was assessed on the basis of a series of commonly used biochemical indicators.
RESULTS AND CONCLUSIONS: For delineation of meaningful ranges of 99mTc-HEPIDA specific hepatic clearance ROC curve method was used. The following results were obtained: ClHp ≥ 150 ml min-1 1.72 m-2 - excludes with high probability presence of substantial liver parenchyma damage; ClHp ≤ 120 ml min-1 1.72m-2 - indicates a substantial impairment of liver function (damage). Values of ClHp ≤ 90 ml min-1 1.72 m-2 are highly specific for serious liver damage, of intensity typical for cirrhosis of the organ.
MATERIAL AND METHODS: To delineate ranges of ClHp that would provide valuable clinical information 134 individuals were studied, of whom 48 served as healthy controls and 86 had varying degrees of livers function impairment, resulting from various chronic diseases affecting the organs functional capacity. The latter was assessed on the basis of a series of commonly used biochemical indicators.
RESULTS AND CONCLUSIONS: For delineation of meaningful ranges of 99mTc-HEPIDA specific hepatic clearance ROC curve method was used. The following results were obtained: ClHp ≥ 150 ml min-1 1.72 m-2 - excludes with high probability presence of substantial liver parenchyma damage; ClHp ≤ 120 ml min-1 1.72m-2 - indicates a substantial impairment of liver function (damage). Values of ClHp ≤ 90 ml min-1 1.72 m-2 are highly specific for serious liver damage, of intensity typical for cirrhosis of the organ.
Keywords: 99mTc-HEPIDA plasma clearancespecific 99mTc-HEPIDA hepatic clearanceclinically essential range