open access
Specific 99mtc-hepida hepatic clearance - essential value ranges from a clinical stand-point
open access
Abstract
MATERIAL AND METHODS: To delineate ranges of ClHp that would provide valuable clinical information 134 individuals were studied, of whom 48 served as healthy controls and 86 had varying degrees of livers function impairment, resulting from various chronic diseases affecting the organs functional capacity. The latter was assessed on the basis of a series of commonly used biochemical indicators.
RESULTS AND CONCLUSIONS: For delineation of meaningful ranges of 99mTc-HEPIDA specific hepatic clearance ROC curve method was used. The following results were obtained: ClHp ≥ 150 ml min-1 1.72 m-2 - excludes with high probability presence of substantial liver parenchyma damage; ClHp ≤ 120 ml min-1 1.72m-2 - indicates a substantial impairment of liver function (damage). Values of ClHp ≤ 90 ml min-1 1.72 m-2 are highly specific for serious liver damage, of intensity typical for cirrhosis of the organ.
Abstract
MATERIAL AND METHODS: To delineate ranges of ClHp that would provide valuable clinical information 134 individuals were studied, of whom 48 served as healthy controls and 86 had varying degrees of livers function impairment, resulting from various chronic diseases affecting the organs functional capacity. The latter was assessed on the basis of a series of commonly used biochemical indicators.
RESULTS AND CONCLUSIONS: For delineation of meaningful ranges of 99mTc-HEPIDA specific hepatic clearance ROC curve method was used. The following results were obtained: ClHp ≥ 150 ml min-1 1.72 m-2 - excludes with high probability presence of substantial liver parenchyma damage; ClHp ≤ 120 ml min-1 1.72m-2 - indicates a substantial impairment of liver function (damage). Values of ClHp ≤ 90 ml min-1 1.72 m-2 are highly specific for serious liver damage, of intensity typical for cirrhosis of the organ.
Keywords
99mTc-HEPIDA plasma clearance; specific 99mTc-HEPIDA hepatic clearance; clinically essential range
Title
Specific 99mtc-hepida hepatic clearance - essential value ranges from a clinical stand-point
Journal
Issue
Pages
56-59
Published online
2006-01-25
Page views
909
Article views/downloads
1054
Bibliographic record
Nucl. Med. Rev 2006;9(1):56-59.
Keywords
99mTc-HEPIDA plasma clearance
specific 99mTc-HEPIDA hepatic clearance
clinically essential range
Authors
Izabela Frieske
Marian J. Surma
Małgorzata Bieńkiewicz
Jacek Kuśmierek