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Vol 13, No 2 (2010)
Review paper
Submitted: 2012-01-23
Published online: 2011-05-20
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Preparation and quality control of 177Lu-[tris(1,10-phenanthroline) lutetium(III)] complex for therapy

Hassan Yousefnia, Amir R. Jalilian, S. Zolghadri, A. Bahrami-Samani, S. Shirvani-Arani, M. Ghannadi-Maragheh
Nucl. Med. Rev 2010;13(2):49-54.

open access

Vol 13, No 2 (2010)
Reviews
Submitted: 2012-01-23
Published online: 2011-05-20

Abstract

The 177Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (177Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 1013 n.cm–2.s–1) of natural Lu2(NO3)3 sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the 177Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.
Nuclear Med Rev 2010; 13, 2: 49–54

Abstract

The 177Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (177Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 1013 n.cm–2.s–1) of natural Lu2(NO3)3 sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the 177Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.
Nuclear Med Rev 2010; 13, 2: 49–54

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Keywords

lutetium-177; 1; 10-phenanthroquinone; biodistribution

About this article
Title

Preparation and quality control of 177Lu-[tris(1,10-phenanthroline) lutetium(III)] complex for therapy

Journal

Nuclear Medicine Review

Issue

Vol 13, No 2 (2010)

Article type

Review paper

Pages

49-54

Published online

2011-05-20

Page views

599

Article views/downloads

2204

Bibliographic record

Nucl. Med. Rev 2010;13(2):49-54.

Keywords

lutetium-177
1
10-phenanthroquinone
biodistribution

Authors

Hassan Yousefnia
Amir R. Jalilian
S. Zolghadri
A. Bahrami-Samani
S. Shirvani-Arani
M. Ghannadi-Maragheh

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