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The diagnostic role of 68Ga-DOTATATE PET/CT in the detection of neuroendocrine tumours
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Abstract
MATERIAL AND METHODS: Between December 2009 and January 2011 ninety-seven patients with confirmed (88 cases) or suspected (9 cases) NET underwent 68Ga DOTATATE PET/CT. The primary, confirmed or suspected, NET localizations were: GEP tumours — 71 patients; medullary thyroid carcinoma — 4 patients; cancer of an unknown primary — 14 patients; and NET in other localisations — 8 patients. PET/CT acquisitions were performed using standard techniques, 45 to 60 minutes after the intravenous injection of 111–185 MBq 68Ga-DOTATATE.
RESULTS: 68Ga-DOTATATE PET/CT detected the presence of lesions demonstrating the somatostatin receptor affinity in 50 of the 97 patients (51.5%) and was negative in 47 patients (48.5%). Among 14 patients with metastatic unknown primary cancer, in 5 patients (45.5%) the primary tumour site was identified, and in 4 patients with medullary thyroid cancer distant metastases with SSTR expression were localized in only one patient.
CONCLUSIONS: Our findings confirm the diagnostic role of 68Ga-DOTATATE PET/CT as an accurate method of identifying primary tumours and distant metastases. It provides information on tumour cell receptors status, which has a significant bearing on planning target radionuclide therapy. Overall, 68Ga-DOTATATE PET/CT can be used in staging, re-staging, and in regular follow up of oncology patients.
Nuclear Med Rev 2011; 14, 1: 16–20
Abstract
MATERIAL AND METHODS: Between December 2009 and January 2011 ninety-seven patients with confirmed (88 cases) or suspected (9 cases) NET underwent 68Ga DOTATATE PET/CT. The primary, confirmed or suspected, NET localizations were: GEP tumours — 71 patients; medullary thyroid carcinoma — 4 patients; cancer of an unknown primary — 14 patients; and NET in other localisations — 8 patients. PET/CT acquisitions were performed using standard techniques, 45 to 60 minutes after the intravenous injection of 111–185 MBq 68Ga-DOTATATE.
RESULTS: 68Ga-DOTATATE PET/CT detected the presence of lesions demonstrating the somatostatin receptor affinity in 50 of the 97 patients (51.5%) and was negative in 47 patients (48.5%). Among 14 patients with metastatic unknown primary cancer, in 5 patients (45.5%) the primary tumour site was identified, and in 4 patients with medullary thyroid cancer distant metastases with SSTR expression were localized in only one patient.
CONCLUSIONS: Our findings confirm the diagnostic role of 68Ga-DOTATATE PET/CT as an accurate method of identifying primary tumours and distant metastases. It provides information on tumour cell receptors status, which has a significant bearing on planning target radionuclide therapy. Overall, 68Ga-DOTATATE PET/CT can be used in staging, re-staging, and in regular follow up of oncology patients.
Nuclear Med Rev 2011; 14, 1: 16–20
Keywords
68Ga-DOTATATE; PET/CT; neuroendocrine tumours
Title
The diagnostic role of 68Ga-DOTATATE PET/CT in the detection of neuroendocrine tumours
Journal
Issue
Article type
Research paper
Pages
16-20
Published online
2011-07-12
Page views
1972
Article views/downloads
2860
Bibliographic record
Nucl. Med. Rev 2011;14(1):16-20.
Keywords
68Ga-DOTATATE
PET/CT
neuroendocrine tumours
Authors
Grażyna Łapińska
Małgorzata Bryszewska
Agnieszka Fijołek-Warszewska
Izabella Kozłowicz-Gudzińska
Paweł Ochman
Agata Sackiewicz-Słaby