open access

Vol 14, No 2 (2011)
Original articles
Published online: 2012-01-04
Submitted: 2012-01-23
Get Citation

The non-conventional use of 99mTc-Tetrofosmine for dynamic hepatobiliary scintigraphy

Cecilia Diana E. Pîglesan, Mircea N. Dragoteanu, Ioana Grigorescu, Constantin Cosma
Nucl. Med. Rev 2011;14(2):79-84.

open access

Vol 14, No 2 (2011)
Original articles
Published online: 2012-01-04
Submitted: 2012-01-23

Abstract

BACKGROUND: Classic dynamic hepatobiliary scintigraphy (DHBS) is commonly performed with 99mTc-Iminodiacetic Acid (IDA) derivatives and represents a non-invasive diagnosis method for biliary dyskinesia, fistulas, surgical anastomosis, etc (1). This study assesses the possibility of performing DHBS with 99mTc-Tetrofosmine (TF), a radiopharmaceutical (RF) dedicated to myocardial perfusion scintigraphy (MPS), but being excreted through the liver. The possibility to use 99mTc-TF for DHBS may be important in situations when the standardized RF for this procedure (IDA derivatives) is not available.
MATERIAL AND METHODS: We performed DHBS for 30 patients referred for investigation by internal medicine and surgery departments. The patients had been fasting for12 hours. The dynamic investigation started simultaneously with the intravenous (IV) administration of 37–110 MBq (1–3 mCi) 99mTc-TF. Dynamic images were recorded for 30–45 minutes, one image per minute, followed by static scintigraphy at 1 h, 1.5 h, 2 h, and 3 h after IV injection.
RESULTS: The quality of scintigraphic images of the liver and biliary tree obtained at DHBS with 99mTc-TF ensured the correct diagnosis of biliary dyskinesia, stasis, stenosis, and fistulas.
CONCLUSIONS: DHBS using 99mTc-TF is justified by the image quality and by the good cost/benefits ratio. Because the IDA derivatives are not always available, this finding may be important for medical practice. 99mTc-TF evacuated through the bile duct allows DHBS interpretation, while the necessary dose is approximately 8 to 20 times smaller than that used for myocardial perfusion scintigraphy.
Nuclear Med Rev 2011; 14, 2: 79–84

Abstract

BACKGROUND: Classic dynamic hepatobiliary scintigraphy (DHBS) is commonly performed with 99mTc-Iminodiacetic Acid (IDA) derivatives and represents a non-invasive diagnosis method for biliary dyskinesia, fistulas, surgical anastomosis, etc (1). This study assesses the possibility of performing DHBS with 99mTc-Tetrofosmine (TF), a radiopharmaceutical (RF) dedicated to myocardial perfusion scintigraphy (MPS), but being excreted through the liver. The possibility to use 99mTc-TF for DHBS may be important in situations when the standardized RF for this procedure (IDA derivatives) is not available.
MATERIAL AND METHODS: We performed DHBS for 30 patients referred for investigation by internal medicine and surgery departments. The patients had been fasting for12 hours. The dynamic investigation started simultaneously with the intravenous (IV) administration of 37–110 MBq (1–3 mCi) 99mTc-TF. Dynamic images were recorded for 30–45 minutes, one image per minute, followed by static scintigraphy at 1 h, 1.5 h, 2 h, and 3 h after IV injection.
RESULTS: The quality of scintigraphic images of the liver and biliary tree obtained at DHBS with 99mTc-TF ensured the correct diagnosis of biliary dyskinesia, stasis, stenosis, and fistulas.
CONCLUSIONS: DHBS using 99mTc-TF is justified by the image quality and by the good cost/benefits ratio. Because the IDA derivatives are not always available, this finding may be important for medical practice. 99mTc-TF evacuated through the bile duct allows DHBS interpretation, while the necessary dose is approximately 8 to 20 times smaller than that used for myocardial perfusion scintigraphy.
Nuclear Med Rev 2011; 14, 2: 79–84
Get Citation

Keywords

biliary; bile tract; cholescintigraphy; dynamic hepatobiliary scintigraphy; liver; tetrofosmin

About this article
Title

The non-conventional use of 99mTc-Tetrofosmine for dynamic hepatobiliary scintigraphy

Journal

Nuclear Medicine Review

Issue

Vol 14, No 2 (2011)

Pages

79-84

Published online

2012-01-04

Bibliographic record

Nucl. Med. Rev 2011;14(2):79-84.

Keywords

biliary
bile tract
cholescintigraphy
dynamic hepatobiliary scintigraphy
liver
tetrofosmin

Authors

Cecilia Diana E. Pîglesan
Mircea N. Dragoteanu
Ioana Grigorescu
Constantin Cosma

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl