COVID-19 pneumonia incidentally discovered on [18F]F-PSMA-1007 PET/CT scan
Abstract
A 75-year-old man underwent a positron emission tomography/computed tomography (PET/CT) scan with fluorine-18-prostate specific membrane antigen ([18F]F-PSMA-1007) for initial staging of prostate adenocarcinoma. The scan showed lung infiltrates predominantly in both lower lobes with moderate uptake, in addition to a bilateral pulmonary hilar lymph node uptake. CT images revealed ground-glass opacities and a reticular pattern, suggesting COVID-19 pneumonia, which was confirmed by reverse transcription polymerase chain reaction (RT-PCR). Similar incidental findings have been reported in patients undergoing PET/CT scans with other radiotracers. In this case, the probable lung angiogenesis linked to COVID-19 infection can be potencially demonstrated by [18F]F-PSMA-1007, which helps ensure timely diagnosis and appropriate care for cancer patients.
Keywords: [18F]F-PSMA-1007PET/CTCOVID-19
References
- Qin C, Liu F, Yen TC, et al. F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. Eur J Nucl Med Mol Imaging. 2020; 47(5): 1281–1286.
- Sahel OA, Benameur Y, Nabih SO, et al. COVID-19 pneumonia was incidentally detected on f-fluorocholine PET/CT in a work-up for prostate cancer. Mol Imaging Radionucl Ther. 2022; 31(3): 231–233.
- Ziolkowska P, Salyga A, Joks M, et al. COVID-19 vaccination-related [18F]FDG-avid lymph node in a patient with marginal zone B-cell lymphoma. Nucl Med Rev. 2023; 26(0): 52–53.
- Dadgar H, Norouzbeigi N, Gholamrezanezhad A, et al. Incidental detections suggestive of COVID-19 in asymptomatic patients undergoing 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT scan for oncological indications. Nuklearmedizin. 2021; 60(2): 106–108.
- Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Engl J Med. 2020; 383(2): 120–128.
- Fang H, Younis MH, Cai W, et al. New wine in old bottles: 68Ga-PSMA-11 PET/CT reveals COVID-19 in patients with prostate cancer. Am J Nucl Med Mol Imaging. 2021; 11(4): 332–336.