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Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with FOLFIRINOX regimen
Affiliations- Department of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland
open access
Abstract
Introduction. Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require constant search of novel prognostic factors. The aim of this study is to determine the role of various morphological parameters in predicting prognosis of advanced PDAC during systemic therapy with FOLFIRINOX regimen.
Material and methods. Data of 52 patients, treated with FOLFIRINOX chemotherapy due to metastatic PDAC were analyzed retrospectively in this study.
Results. Median time of overall survival (OS) in group of patients with neutrophil-to-lymphocyte ratio (NLR) ≥3 was 5.8 months, compared to 14.5 months in patients with NLR < 3. Median progression free survival (PFS) in patients with NLR ≥ 3 was 4.1 months, compared to 8.5 months in patients with NLR < 3. There were no statistically significant differences among patients concerning lymphocyte-to-monocyte ratio (LMR) and platelets-to-lymphocyte ratio (PLR).
Conclusions. Higher NLR is a negative prognostic factor in metastatic PDAC.
Abstract
Introduction. Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require constant search of novel prognostic factors. The aim of this study is to determine the role of various morphological parameters in predicting prognosis of advanced PDAC during systemic therapy with FOLFIRINOX regimen.
Material and methods. Data of 52 patients, treated with FOLFIRINOX chemotherapy due to metastatic PDAC were analyzed retrospectively in this study.
Results. Median time of overall survival (OS) in group of patients with neutrophil-to-lymphocyte ratio (NLR) ≥3 was 5.8 months, compared to 14.5 months in patients with NLR < 3. Median progression free survival (PFS) in patients with NLR ≥ 3 was 4.1 months, compared to 8.5 months in patients with NLR < 3. There were no statistically significant differences among patients concerning lymphocyte-to-monocyte ratio (LMR) and platelets-to-lymphocyte ratio (PLR).
Conclusions. Higher NLR is a negative prognostic factor in metastatic PDAC.
Keywords
pancreatic ductal carcinoma; chemotherapy; overall survival; time to progression; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; platelets-to-lymphocyte ratio
About this articleTitle
Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with FOLFIRINOX regimen
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Published online
2023-02-23
Page views
20
Article views/downloads
22
DOI
10.5603/NJO.a2023.0009
Keywords
pancreatic ductal carcinoma
chemotherapy
overall survival
time to progression
neutrophil-to-lymphocyte ratio
lymphocyte-to-monocyte ratio
platelets-to-lymphocyte ratio
Authors
Małgorzata Domagała-Haduch
Jakub Wnuk
Łukasz Michalecki
Iwona Gisterek
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