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Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with a FOLFIRINOX regimen
, 1, 1, 1
Affiliations- Department of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland
open access
Abstract
Introduction.Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require a constant search for novel prognostic factors. The aim of this study is to determine the role of various morphological parameters in predicting the prognosis of advanced PDAC during systemic therapy with a FOLFIRINOX regimen.
Material and methods.The data of 52 patients, treated with FOLFIRINOX chemotherapy due to metastatic PDAC were analyzed retrospectively in this study.
Results.The median time of overall survival (OS) in the group of patients with neutrophil-to-lymphocyte ratio (NLR) ≥3 was 5.8 months, compared to 14.5 months in patients with NLR < 3. Median progression-free survival (PFS) in patients with NLR ≥ 3 was 4.1 months, compared to 8.5 months in patients with NLR < 3. There were no statistically significant differences among patients concerning the lymphocyte-to-monocyte ratio (LMR) and platelets-to-lymphocyte ratio (PLR).
Conclusions.Higher NLR is a negative prognostic factor in metastatic PDAC.
Abstract
Introduction.Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require a constant search for novel prognostic factors. The aim of this study is to determine the role of various morphological parameters in predicting the prognosis of advanced PDAC during systemic therapy with a FOLFIRINOX regimen.
Material and methods.The data of 52 patients, treated with FOLFIRINOX chemotherapy due to metastatic PDAC were analyzed retrospectively in this study.
Results.The median time of overall survival (OS) in the group of patients with neutrophil-to-lymphocyte ratio (NLR) ≥3 was 5.8 months, compared to 14.5 months in patients with NLR < 3. Median progression-free survival (PFS) in patients with NLR ≥ 3 was 4.1 months, compared to 8.5 months in patients with NLR < 3. There were no statistically significant differences among patients concerning the lymphocyte-to-monocyte ratio (LMR) and platelets-to-lymphocyte ratio (PLR).
Conclusions.Higher NLR is a negative prognostic factor in metastatic PDAC.
Keywords
pancreatic ductal carcinoma; chemotherapy, overall survival; time to progression; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; platelets-to-lymphocyte ratio
About this articleTitle
Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with a FOLFIRINOX regimen
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
59-62
Published online
2023-02-23
Page views
1880
Article views/downloads
238
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2023;73(2):59-62.
Keywords
pancreatic ductal carcinoma
chemotherapy
overall survival
time to progression
neutrophil-to-lymphocyte ratio
lymphocyte-to-monocyte ratio
platelets-to-lymphocyte ratio
Authors
Małgorzata Domagała-Haduch
Jakub Wnuk
Łukasz Michalecki
Iwona Gisterek
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