open access

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Review paper
Published online: 2022-12-16
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Radiotherapy and immunotherapy

Ewa Sierko12
DOI: 10.5603/NJO.a2022.0062
Affiliations
  1. Radiotherapy Department 1, Bialystok Oncology Centre, Bialystok, Poland
  2. Oncology Clinic, Medical University of Bialystok, Bialystok, Poland

open access

Ahead of print
Review article
Published online: 2022-12-16

Abstract

Radiation therapy is one of the standard treatment method in cancer patients. Apart from exerting the killing effect towards cancer cells it produces modulation effect on local and systemic disease. Recently, immunotherapy, aiming mainly to immune checkpoint blockade, has become widely used in many clinical situations. Experimental and clinical studies indicate that the combination of both radiation therapy and immunotherapy may be beneficial in cancer patient population in different clinical scenarios. Durvalumab maintenance therapy after radiochemotherapy in stage III NSCLC patients was introduced to the standard clinical care. The paper discusses shortly the pathogenesis of the mutual interaction between radiation therapy and immunotherapy as well available preclinical and clinical data concerning this promising treatment combination.

Abstract

Radiation therapy is one of the standard treatment method in cancer patients. Apart from exerting the killing effect towards cancer cells it produces modulation effect on local and systemic disease. Recently, immunotherapy, aiming mainly to immune checkpoint blockade, has become widely used in many clinical situations. Experimental and clinical studies indicate that the combination of both radiation therapy and immunotherapy may be beneficial in cancer patient population in different clinical scenarios. Durvalumab maintenance therapy after radiochemotherapy in stage III NSCLC patients was introduced to the standard clinical care. The paper discusses shortly the pathogenesis of the mutual interaction between radiation therapy and immunotherapy as well available preclinical and clinical data concerning this promising treatment combination.

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Keywords

radiation therapy; radiotherapy; immunotherapy; checpoint inhibitors; cancer

About this article
Title

Radiotherapy and immunotherapy

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Review paper

Published online

2022-12-16

Page views

26

Article views/downloads

19

DOI

10.5603/NJO.a2022.0062

Keywords

radiation therapy
radiotherapy
immunotherapy
checpoint inhibitors
cancer

Authors

Ewa Sierko

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