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Treatment of metastatic uveal melanoma

Mateusz M. Polaczek1, Hanna Koseła-Paterczyk1
DOI: 10.5603/NJO.a2022.0057
Affiliations
  1. Department of Soft Tissue/Bone Sarcoma and Melanoma; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

open access

Ahead of print
Review article
Published online: 2022-10-12

Abstract

Uveal melanoma is a rare malignancy with a poor prognosis. The risk of metastatic disease (mainly to the liver) exceeds 50% and is often observed many years after the primary treatment. The methods of local surgical treatment of metastatic lesions in the liver provide some chance for long-term survival but are possible in a small percentage of patients. The therapies currently used as a standard for cutaneous melanoma are not as effective in ocular melanoma. The first drug that prolongs the survival of patients is tebentafusp, but its applicability depends on the presence of HLA-A * 02: 01 expression.

Abstract

Uveal melanoma is a rare malignancy with a poor prognosis. The risk of metastatic disease (mainly to the liver) exceeds 50% and is often observed many years after the primary treatment. The methods of local surgical treatment of metastatic lesions in the liver provide some chance for long-term survival but are possible in a small percentage of patients. The therapies currently used as a standard for cutaneous melanoma are not as effective in ocular melanoma. The first drug that prolongs the survival of patients is tebentafusp, but its applicability depends on the presence of HLA-A * 02: 01 expression.

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Keywords

uveal melanoma; local treatment; immunotherapy

About this article
Title

Treatment of metastatic uveal melanoma

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Review paper

Published online

2022-10-12

Page views

39

Article views/downloads

56

DOI

10.5603/NJO.a2022.0057

Keywords

uveal melanoma
local treatment
immunotherapy

Authors

Mateusz M. Polaczek
Hanna Koseła-Paterczyk

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